GALNT3

Last Update:2015-10-27

This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT3 is the third member of this enzyme family. In general, this isozyme exhibits strong activities toward continuous S/T sequence, producing the triplet Tn-structure.

Keyword: O-glycan ,  Tn-antigen ,  mucin ,  tumor marker
HO-Ser/Thr
UDP-GalNAc 		GalNAc(alpha1-O)-Ser/Thr

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase


GGDB Symbol GALNT3    Alias
DesignationUDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3
OrganismHomo sapiens
GeneID 2591
HGNC GALNT3 (4125)
mRNA NM_004482
map2q24-q31
Protein NP_004473
EC# 2.4.1.41   
CAZy GT27   
GlyCosmos Glycogenes GALNT3
OMIM 601756
Disease name
GDGDB
Human Protein Atlas ENSG00000115339
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "GALNT3".