This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT7 is the seventh member of this enzyme family. This exhibits strong activities toward GalNAc-glycosylated peptide.
Keyword:
O-glycan
, Tn-antigen
, mucin
, tumor marker
HO-Ser/Thr (Glycopeptide)
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UDP-GalNAc
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GalNAc(alpha1-O)-Ser/Thr (Glycopeptide)
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UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
FEBS Lett. 1999-10-01 ;460(2):226-30.
A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates.
Bennett EP. et al.
PMID:10544240
adrenal glandslymph nodespinal cordstomachthyroid glandtrachea
This page does not indicate all of the enzymatic reaction, and expression of "GALNT7".