GGDB:

この酵素は、供与体基質UDP-GalNAcからタンパク質のセリンまたはスレオニン残基にGalNAcを転移する活性を持つ。反応生成物は広くTn-抗原として知られているGalNAc-alpha-O-Ser/Thr構造で、ムチン型O-グリカンの根本の構造である。受容体基質であるタンパク質の典型はムチンである。このアイソザイムはこのファミリーの7番目のメンバーである。このアイソザイムはGalNAc修飾されたペプチドに対して強い活性を示す。

Keyword: O-グリカン , Tn抗原 , ムチン , 腫瘍マーカー

HO-Ser/Thr (Glycopeptide)	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr (Glycopeptide)

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

GGDB Symbol

GALNT7 Alias

Designation

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7

Organism

Homo sapiens

GeneID

51809

HGNC

GALNT7 (4129)

mRNA

BC047468

map

4q31.1

Protein

AAH47468

EC#

2.4.1.41

CAZy

GT27

GlyCosmos Glycogenes

GALNT7

OMIM

605005

Disease name

GDGDB

Human Protein Atlas

ENSG00000109586

Mus musculus

mRNA	NM_144731
Protein	NP_653332
MGI	43800

Rattus norvegicus

mRNA	NM_022926
Protein	NP_075215

Caenorhabditis elegans

mRNA	NM_071111
Protein	NP_503512

Drosophila melanogaster

mRNA	NM_167623
Protein	NP_728178

FEBS Lett. 1999-10-01 ;460(2):226-30.

A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates.

Bennett EP. et al. PMID:10544240

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	HO-Ser/Thr (Glycopeptide)	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr (Glycopeptide)

Table 1 Substrate specificities of semi-purified recombinant GalNAc-T4 and T7
Peptide (sequence)	specific activity (milliunits/ml)
Glycosylated-Muc2 (PTTTPISTTTMVTPTPTPTC)	10.3
Glycosylated-EA2 (DSTTPAPTTK)	4.2
Glycosylated-Muc7 (Ac-CPPTPSATTPAPPSSSAPPETTAA)	0.4
EA2 (DSTTPAPTTK)	0.3
Glycosylated-Muc5AC (Ac-SAPTTSTTSAPT)	0.3
Muc5AC (Ac-SAPTTSTTSAPT)	0.1
Muc7 (Ac-CPPTPSATTPAPPSSSAPPETTAA)	0.0
Glycosylated-TAP24 (TAPPAHGVTSAPDTRPAPGSTAPPA)	0.0
TAP24 (TAPPAHGVTSAPDTRPAPGSTAPPA)	0.0
Muc2 (PTTTPISTTTMVTPTPTPTC)	0.0

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

FEBS Lett. 1999-10-01 ;460(2):226-30.

A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates.

Bennett EP. et al. PMID:10544240

adrenal glandslymph nodespinal cordstomachthyroid glandtrachea

Provided by GOA

Function
carbohydrate binding
metal ion binding
polypeptide N-acetylgalactosaminyltransferase activity

Process
O-glycan processing
carbohydrate metabolic process
protein O-linked glycosylation

Component
Golgi membrane
extracellular exosome
integral component of membrane
membrane

GALNT7

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates.

DONOR : UDP-GalNAc

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates.

Gene Ontology