This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT10 is the tenth member of this enzyme family. This exhibits strong activities toward GalNAc-glycosylated peptide. Lectin domain is functional to recognize GalNAc-glycosylated peptide substrate by X-ray crystallography by Kubota et al. (2006).
Keyword:
O-glycan
, Tn-antigen
, mucin
, tumor marker
| HO-Ser/Thr (Glycopeptide) | 
|
GalNAc(alpha1-O)-Ser/Thr (Glycopeptide) |
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
| GALNT10 Alias | |
| Designation | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10 |
| Organism | Homo sapiens |
| GeneID | 55568 |
| HGNC | GALNT10 (19873) |
| mRNA | NM_198321 |
| map | 5q33.2 |
| Protein | NP_938080 |
| EC# | 2.4.1.41 |
| CAZy | GT27 |
| GlyCosmos Glycogenes | GALNT10 |
| OMIM | 608043 |
| GDGDB | |
| Human Protein Atlas | ENSG00000164574 |
Mus musculus
Rattus norvegicus
Caenorhabditis elegans
Drosophila melanogaster
