GGDB:

この酵素は、供与体基質UDP-GalNAcからタンパク質のセリンまたはスレオニン残基にGalNAcを転移する活性を持つ。反応生成物は広くTn-抗原として知られているGalNAc-alpha-O-Ser/Thr構造で、ムチン型O-グリカンの根本の構造である。受容体基質であるタンパク質の典型はムチンである。このアイソザイムはファミリーの11番目のメンバーで、腎臓のみに選択的に発現しており、非冗長的な機能を持つことが推定される。

Keyword: O-グリカン , Tn抗原 , ムチン , 腫瘍マーカー

HO-Ser/Thr	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

GGDB Symbol

GALNT11 Alias

Designation

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11

Organism

Homo sapiens

GeneID

63917

HGNC

GALNT11 (19875)

mRNA

NM_022087

map

7q34-q36

Protein

NP_071370

EC#

2.4.1.41

CAZy

GT27

GlyCosmos Glycogenes

GALNT11

OMIM

615130

Disease name

GDGDB

Human Protein Atlas

ENSG00000178234

Mus musculus

mRNA	NM_144908
Protein	NP_659157
MGI	85350

Rattus norvegicus

mRNA	NM_199393
Protein	NP_955425

Caenorhabditis elegans

mRNA	NM_067181
Protein	NP_499582

Drosophila melanogaster

mRNA	NM_143812
Protein	NP_652069

J. Biol. Chem. 2002-06-01 ;277(25):22623-38.

Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

Schwientek T. et al. PMID:11925450

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	HO-Ser/Thr	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr

Table II Acceptor substrate specificities of human GalNAc-T11 and Drosophila dGalNAc-T1
Acceptor peptide (sequence)	Specific Activity (milliunits/ml)
EA2 (PTTDSTTPAPTTK)	210
Muc2 (PTTTPISTTTMVTPTPTPTC)	170
Muc4.1 (CPLPVTDTSSASTGHATPLPV)	130
Muc4.3 (TGHATPLPV)	90
Muc1 (60-mer) (VTSAPDTRPAPGSTAPPAHG)*3	90
Muc1a' (AHGVTSAPDTR)	80
Muc5.1 (CTTSTTSAPTTSTTSAPTTS)	60
Muc7 (CPPTPSATTPAPPSSSAPPETTAA)	60
T. cruzi (TTTKPPTTTTTTTTKPPTTT)	30
Muc1b' (RPAPGSTAPPA)	30
EPO-T (PPDAATAAPLR)	10
TPA (AATAATPATTA)	10
TAA (AATPATAATTA)	10

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2002-06-01 ;277(25):22623-38.

Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

Schwientek T. et al. PMID:11925450

brainheartkidneyplacentaskeletal muscle

Provided by GOA

Function
Notch binding
carbohydrate binding
metal ion binding
polypeptide N-acetylgalactosaminyltransferase activity

Process
Notch receptor processing
Notch signaling involved in heart development
O-glycan processing
cilium morphogenesis
determination of left/right symmetry
protein O-linked glycosylation via threonine
regulation of Notch signaling pathway

Component
Golgi membrane
integral component of membrane

GALNT11

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

DONOR : UDP-GalNAc

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

Gene Ontology