This enzyme catalyzes the GalNAc transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT12 is the twelfth member of this enzyme family. This isozyme is expressed in digestive organ.
Keyword:
O-glycan
, Tn-antigen
, mucin
, tumor marker
HO-Ser/Thr
UDP-GalNAc
GalNAc(alpha1-O)-Ser/Thr
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
GGDB Symbol
GALNT12
Alias
HGNC Symbol
:
GALNT12
historical
:
GalNAc-T12
clone name
:
FLJ21212
related terminology
:
CRCS1
Designation UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12
Organism Homo sapiens
GeneID
79695
HGNC
GALNT12
(19877 )
mRNA
AJ132365
map 9q22.33
Protein
CAC80100
EC#
2.4.1.41
CAZy
GT27
GlyCosmos Glycogenes
GALNT12
OMIM
610290
Disease name
GDGDB
Human Protein Atlas
ENSG00000119514
RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas.
Tissue RNA Expression
Cerebral cortex Cerebellum Hippocampal formation Amygdala Thalamus Hypothalamus Basal ganglia Choroid plexus Midbrain Pons Medulla oblongata Spinal cord White matter Bone marrow Spleen Thymus Lymph node Tonsil Appendix Thyroid gland Parathyroid gland Adrenal gland Lung Heart muscle Smooth muscle Skeletal muscle Salivary gland Tongue Esophagus Stomach Duodenum Small intestine Colon Rectum Liver Gallbladder Pancreas Kidney Urinary bladder Testis Epididymis Seminal vesicle Prostate Ovary Fallopian tube Endometrium Cervix Placenta Breast Adipose tissue Skin 0 20 40 60
Brain Bone marrow & Lymphoid tissues Endocrine tissues Respiratory system Muscle tissues Proximal digestive tract Gastrointestinal tract Liver & Gallbladder Pancreas Kidney & Urinary bladder Male reproductive system Breast and female reproductive system Connective & Soft tissue Skin Tissue group nTPM data available from v22.proteinatlas.org
FEBS Lett. 2002-07-01 ;524(1-3):211-8.
Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.
Guo JM. et al.
PMID:12135769
adrenal glands bone marrow brain cerebellum cerebral cortex colon esophagus fetal brain heart kidney liver lung mammary gland melanoma ovary pancreas peripheral blood leukocyte placenta skeletal muscle small intestine spleen stomach testis thymus thyroid gland uterus
This page does not indicate all of the enzymatic reaction, and expression of "GALNT12".
Mus musculus
Rattus norvegicus
Caenorhabditis elegans
Drosophila melanogaster