GGDB:

この酵素は、供与体基質UDP-GalNAcからタンパク質のセリンまたはスレオニン残基にGalNAcを転移する活性を持つ。反応生成物は広くTn-抗原として知られているGalNAc-alpha-O-Ser/Thr構造で、ムチン型O-グリカンの根本の構造である。受容体基質であるタンパク質の典型はムチンである。このアイソザイムはファミリーの12番目のメンバーであり消化器官で発現される。

Keyword: O-グリカン , Tn抗原 , ムチン , 腫瘍マーカー

HO-Ser/Thr	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

GGDB Symbol

GALNT12 Alias

Designation

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12

Organism

Homo sapiens

GeneID

79695

HGNC

GALNT12 (19877)

mRNA

AJ132365

map

9q22.33

Protein

CAC80100

EC#

2.4.1.41

CAZy

GT27

GlyCosmos Glycogenes

GALNT12

OMIM

610290

Disease name

GDGDB

Human Protein Atlas

ENSG00000119514

Mus musculus

mRNA	NM_172693
Protein	NP_766281
MGI	85568

Rattus norvegicus

mRNA	XM_232988
Protein	XP_232988

Caenorhabditis elegans

mRNA	NM_067320
Protein	NP_499721

Drosophila melanogaster

mRNA	NM_166188
Protein	NP_725602

FEBS Lett. 2002-07-01 ;524(1-3):211-8.

Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.

Guo JM. et al. PMID:12135769

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	HO-Ser/Thr	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

FEBS Lett. 2002-07-01 ;524(1-3):211-8.

Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.

Guo JM. et al. PMID:12135769

adrenal glandsbone marrowbraincerebellumcerebral cortexcolonesophagusfetal brainheartkidneyliverlungmammary glandmelanomaovarypancreasperipheral blood leukocyteplacentaskeletal musclesmall intestinespleenstomachtestisthymusthyroid glanduterus

Provided by GOA

Function
carbohydrate binding
metal ion binding
polypeptide N-acetylgalactosaminyltransferase activity

Process
O-glycan processing

Component
Golgi membrane
integral component of membrane

GALNT12

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.

DONOR : UDP-GalNAc

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.

Gene Ontology