GGDB:

This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT13 is the 13th member of this enzyme family. This isozyme is highly homologous to GALNT1, however this is specifically expressed in neurons, suggesting the synthesis of neuron specific Tn-antigens.

Keyword: O-glycan , Tn-antigen , mucin , tumor marker

HO-Ser/Thr	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

GGDB Symbol

GALNT13 Alias

Designation

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13

Organism

Homo sapiens

GeneID

114805

HGNC

GALNT13 (23242)

mRNA

NM_052917

map

2q23.3-q24.1

Protein

NP_443149

EC#

2.4.1.41

CAZy

GT27

GlyCosmos Glycogenes

GALNT13

OMIM

608369

Disease name

GDGDB

Human Protein Atlas

ENSG00000144278

Mus musculus

mRNA	NM_173030
Protein	NP_766618
MGI	66887

Rattus norvegicus

mRNA	NM_199106
Protein	NP_954537

Caenorhabditis elegans

mRNA	NM_066321
Protein	NP_498722

Drosophila melanogaster

mRNA	AY060338
Protein	AAL25377

J. Biol. Chem. 2003-01-01 ;278(1):573-84.

Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

Zhang Y. et al. PMID:12407114

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	HO-Ser/Thr	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr

Table I Kinetic constants of purified recombinant pp-GalNAc-Ts
Peptide (sequence)	Vmax (nmol/min/？g)
SDC106 (AVSTTPAVLK-FAM)	2.00
SDC155 (ATTVSTTMAK-FAM)	1.17
SDC165 (ATTAATSTGDPTVAK-FAM)	0.71
Muc1a' (FAM-AHGVTSAPDTR)	0.65
Muc7 (PTPSATTPAPPSSSAPPETTAAK-FAM)	0.41
SDC284 (GPTEVAQTPTPETFLTTIK-FAM)	0.21

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2003-01-01 ;278(1):573-84.

Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

Zhang Y. et al. PMID:12407114

bladderbraincerebellumcerebral cortexcolonfetal brainfetal kidneyfetal lungfetal small intestinefetal spleenlungmammary glandovarypancreasplacentasmall intestinestomachtestisuterus

Provided by GOA

Function
carbohydrate binding
metal ion binding
polypeptide N-acetylgalactosaminyltransferase activity

Process
O-glycan processing

Component
Golgi membrane
integral component of membrane

GALNT13

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

DONOR : UDP-GalNAc

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

Gene Ontology