GGDB:

この酵素は、供与体基質UDP-GalNAcからタンパク質のセリンまたはスレオニン残基にGalNAcを転移する活性を持つ。反応生成物は広くTn-抗原として知られているGalNAc-alpha-O-Ser/Thr構造で、ムチン型O-グリカンの根本の構造である。受容体基質であるタンパク質の典型はムチンである。このアイソザイムはファミリーの13番目のメンバーである。GALNT1と高度に相同性があるが神経細胞で特異的に発現しており、神経特異的Tn抗原の合成が示唆されている。

Keyword: O-グリカン , Tn抗原 , ムチン , 腫瘍マーカー

HO-Ser/Thr	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

GGDB Symbol

GALNT13 Alias

Designation

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13

Organism

Homo sapiens

GeneID

114805

HGNC

GALNT13 (23242)

mRNA

NM_052917

map

2q23.3-q24.1

Protein

NP_443149

EC#

2.4.1.41

CAZy

GT27

GlyCosmos Glycogenes

GALNT13

OMIM

608369

Disease name

GDGDB

Human Protein Atlas

ENSG00000144278

Mus musculus

mRNA	NM_173030
Protein	NP_766618
MGI	66887

Rattus norvegicus

mRNA	NM_199106
Protein	NP_954537

Caenorhabditis elegans

mRNA	NM_066321
Protein	NP_498722

Drosophila melanogaster

mRNA	AY060338
Protein	AAL25377

J. Biol. Chem. 2003-01-01 ;278(1):573-84.

Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

Zhang Y. et al. PMID:12407114

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	HO-Ser/Thr	UDP-GalNAc	GalNAc(alpha1-O)-Ser/Thr

Table I Kinetic constants of purified recombinant pp-GalNAc-Ts
Peptide (sequence)	Vmax (nmol/min/？g)
SDC106 (AVSTTPAVLK-FAM)	2.00
SDC155 (ATTVSTTMAK-FAM)	1.17
SDC165 (ATTAATSTGDPTVAK-FAM)	0.71
Muc1a' (FAM-AHGVTSAPDTR)	0.65
Muc7 (PTPSATTPAPPSSSAPPETTAAK-FAM)	0.41
SDC284 (GPTEVAQTPTPETFLTTIK-FAM)	0.21

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2003-01-01 ;278(1):573-84.

Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

Zhang Y. et al. PMID:12407114

bladderbraincerebellumcerebral cortexcolonfetal brainfetal kidneyfetal lungfetal small intestinefetal spleenlungmammary glandovarypancreasplacentasmall intestinestomachtestisuterus

Provided by GOA

Function
carbohydrate binding
metal ion binding
polypeptide N-acetylgalactosaminyltransferase activity

Process
O-glycan processing

Component
Golgi membrane
integral component of membrane

GALNT13

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

DONOR : UDP-GalNAc

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

Gene Ontology