This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT15 is the 15th member of this enzyme family. This isozyme exhibits unique catalytic activity producing multiple-GalNAc peptides.
Keyword:
O-glycan
, Tn-antigen
, mucin
, tumor marker
| HO-Ser/Thr | 
|
GalNAc(alpha1-O)-Ser/Thr |
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
| GALNT15 Alias | |
| Designation | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T15 |
| Organism | Homo sapiens |
| GeneID | 117248 |
| HGNC | GALNTL2 (21531) |
| mRNA | AB078149 |
| map | 3p25.1 |
| Protein | BAD29961 |
| EC# | 2.4.1.41 |
| CAZy | GT27 |
| GlyCosmos Glycogenes | GALNT15 |
| OMIM | 615131 |
| GDGDB | |
| Human Protein Atlas | ENSG00000131386 |
Mus musculus
Rattus norvegicus
