GGDB:

beta-1,3-N-acetylgalactosaminyltransferase 1 (β3GalNAcT1: B3GALNT1) is the enzyme that synthesizes globosides. B3GALNT1 was initially isolated as β3GalT3 (B3GALT3) without the GalT activity by “in silico cloning” from the similarity of their sequences. However, thereafter, Okajima and colleagues reported that β3GalNAc-T1 cloned as the globoside (Gb4) synthase was actually the same as β3Gal-T3.

Keyword: Globoside Synthase , globo-series glycolipid

N-Acetylgalactosaminyltransferase

GGDB Symbol

B3GALNT1 Alias

Designation

beta 1,3-N-acetylgalactosaminyltransferase 1

Organism

Homo sapiens

GeneID

8706

HGNC

B3GALNT1 (918)

mRNA

NM_003781

map

3q25

Protein

NP_003772

EC#

2.4.1.79

CAZy

GT31

GlyCosmos Glycogenes

B3GALNT1

OMIM

603094

Disease name

GDGDB

Human Protein Atlas

ENSG00000169255

Mus musculus

mRNA	NM_020026
Protein	NP_064410
MGI	43756

Rattus norvegicus

mRNA	BC079206
Protein	AAH79206

J. Biol. Chem. 2000-12-01 ;275(51):40498-503.

Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.

Okajima T. et al. PMID:10993897

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR002182 GlyTouCan: G00059MO GlyCosmos Glycans: G00059MO	UDP-GalNAc	JCGG-STR026907 GlyTouCan: G00061MO GlyCosmos Glycans: G00061MO

Substrate Not Transferred

	JCGG-STR026907 GlyTouCan: G00061MO GlyCosmos Glycans: G00061MO

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK

	JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH

J. Biol. Chem. 1984-05-01 ;259(9):5637-42.

Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen.

Taniguchi N. et al. PMID:6425294

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2000-12-01 ;275(51):40498-503.

Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.

Okajima T. et al. PMID:10993897

brainheartkidneyliverlungplacentaspleenstomachtestis

Provided by GOA

Function
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity

Process
oligosaccharide biosynthetic process
protein glycosylation

Component
Golgi membrane
integral component of membrane

B3GALNT1

N-Acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.

DONOR : UDP-GalNAc

Substrate Transferred

Substrate Not Transferred

Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.

Gene Ontology