GGDB:

本遺伝子はガングリオシド（ガングリオ系糖脂質）である、GM2あるいはGD2、asialo-GM2 (GA2)の合成に関与する酵素をコードする。この酵素は、糖供与体UDP-GalNAcからGalNAcをb1-4結合で糖受容体基質（LacCer, GM3, GD3 glycolipid）に転移する活性を有する。

Keyword: GD2 , GM2 , asialo-GM2 (GA2) , ガングリオシド , ガングリオ系糖脂質

	UDP-GalNAc
JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW		JCGG-STR003580 GlyTouCan: G90562PB GlyCosmos Glycans: G90562PB

	UDP-GalNAc
JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK		JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

N-Acetylgalactosaminyltransferase

GGDB Symbol

B4GALNT1 Alias

Designation

beta-1,4-N-acetylgalactosaminyltransferase 1, GM2/GD2 synthase

Organism

Homo sapiens

GeneID

2583

HGNC

B4GALNT1 (4117)

mRNA

NM_001478

map

12q13.3

Protein

NP_001469

EC#

2.4.1.92

CAZy

GT12

GlyCosmos Glycogenes

B4GALNT1

OMIM

601873

Disease name

GDGDB

Human Protein Atlas

ENSG00000135454

mRNA	NM_008080
Protein	NP_032106
MGI	41752

mRNA	NM_022860
Protein	NP_074051

J. Biol. Chem. 1992-06-01 ;267(17):12082-9.

Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides.

Nagata Y. et al. PMID:1601877 Refer to: Figure 6,Figure 7

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	UDP-GalNAc	JCGG-STR003580 GlyTouCan: G90562PB GlyCosmos Glycans: G90562PB

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK	UDP-GalNAc	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK	UDP-GalNAc	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH	UDP-GalNAc	JCGG-STR004909 GlyTouCan: G02657AK GlyCosmos Glycans: G02657AK

J. Biol. Chem. 1995-03-01 ;270(11):6149-55.

Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.

Yamashiro S. et al. PMID:7890749 Refer to: TABLE I

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK	UDP-GalNAc	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	JCGG-STR026525 GlyTouCan: G75789AR GlyCosmos Glycans: G75789AR	UDP-GalNAc	JCGG-STR009731 GlyTouCan: G56478LD GlyCosmos Glycans: G56478LD

	JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH	UDP-GalNAc	JCGG-STR004909 GlyTouCan: G02657AK GlyCosmos Glycans: G02657AK

	JCGG-STR027108 GlyTouCan: G01767JJ GlyCosmos Glycans: G01767JJ	UDP-GalNAc	JCGG-STR009720 GlyTouCan: G13224CR GlyCosmos Glycans: G13224CR

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	UDP-GalNAc	JCGG-STR003580 GlyTouCan: G90562PB GlyCosmos Glycans: G90562PB

Substrate Not Transferred

	JCGG-STR024659 GlyTouCan: G46677TE GlyCosmos Glycans: G46677TE

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR005131 GlyTouCan: G40183QN GlyCosmos Glycans: G40183QN

	JCGG-STR012155 GlyTouCan: G03361KC GlyCosmos Glycans: G03361KC

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF

B4GALNT1

N-Acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides.

DONOR : UDP-GalNAc

Substrate Transferred

Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.

DONOR : UDP-GalNAc

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Gene Ontology