GGDB:

B4GALNT2 encodes beta-1,4-N-acetyl-galactosaminyltransferase 2. This enzyme transfers GalNAc from the donor substrate, UDP-GalNAc, to the acceptor substrate, (NeuAcα2-3)Gal-, via a beta1,4 linkage to form the Sda blood group antigen (GalNAcβ1-4(NeuAcα2-3)Galβ1-R ) or the CAD antigen ( GalNAcβ1-4(NeuAcα2-3)Galβ1-R). This enzyme is highly expressed in the normal digestive tract and is known to be epigenetically repressed by methylation in oncogenesis.

Keyword: CAD antigen , Sda antigen

	UDP-GalNAc
JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR		JCGG-STR031529 GlyTouCan: G39040YX GlyCosmos Glycans: G39040YX

	UDP-GalNAc
JCGG-STR031358 GlyTouCan: G79536OW GlyCosmos Glycans: G79536OW		JCGG-STR031362 GlyTouCan: G10112QT GlyCosmos Glycans: G10112QT

	UDP-GalNAc
JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK		JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	UDP-GalNAc
JCGG-STR031609 GlyTouCan: G43761FR GlyCosmos Glycans: G43761FR		JCGG-STR031530

	UDP-GalNAc
JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR		JCGG-STR031529 GlyTouCan: G39040YX GlyCosmos Glycans: G39040YX

N-Acetylgalactosaminyltransferase

GGDB Symbol

B4GALNT2 Alias

Designation

beta 1,4 N-acetylgalactosaminyltransferase 2

Organism

Homo sapiens

GeneID

124872

HGNC

B4GALNT2 (24136)

mRNA

NM_153446

map

17q21.32

Protein

NP_703147

EC#

CAZy

GT12

GlyCosmos Glycogenes

B4GALNT2

OMIM

111730

Disease name

GDGDB

Human Protein Atlas

ENSG00000167080

Mus musculus

mRNA	NM_008081
Protein	NP_032107
MGI	41753

Biochem. J. 2003-07-01 ;373(Pt 2):369-79.

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

Montiel MD. et al. PMID:12678917 Refer to: Table 1

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR	UDP-GalNAc	JCGG-STR031529 GlyTouCan: G39040YX GlyCosmos Glycans: G39040YX

	JCGG-STR031358 GlyTouCan: G79536OW GlyCosmos Glycans: G79536OW	UDP-GalNAc	JCGG-STR031362 GlyTouCan: G10112QT GlyCosmos Glycans: G10112QT

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK	UDP-GalNAc	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	JCGG-STR031526 GlyTouCan: G64527IJ GlyCosmos Glycans: G64527IJ	UDP-GalNAc	JCGG-STR031620 GlyTouCan: G36502OW GlyCosmos Glycans: G36502OW

	JCGG-STR031609 GlyTouCan: G43761FR GlyCosmos Glycans: G43761FR	UDP-GalNAc	JCGG-STR031530

	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR	UDP-GalNAc	JCGG-STR031529 GlyTouCan: G39040YX GlyCosmos Glycans: G39040YX

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE	UDP-GalNAc	JCGG-STR031531 GlyTouCan: G42797SX GlyCosmos Glycans: G42797SX

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO	UDP-GalNAc	JCGG-STR031618 GlyTouCan: G52935RP GlyCosmos Glycans: G52935RP

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	UDP-GalNAc	JCGG-STR031619 GlyTouCan: G31894FR GlyCosmos Glycans: G31894FR

Substrate Not Transferred

	JCGG-STR027263 GlyTouCan: G20044TD GlyCosmos Glycans: G20044TD

	JCGG-STR025461 GlyTouCan: G68639CF GlyCosmos Glycans: G68639CF

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR031360 GlyTouCan: G43804GS GlyCosmos Glycans: G43804GS

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK

	JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH

	JCGG-STR031354 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI

table 1
Glycoprotein	Enzyme activity
Fetuin	2
[alpha]1-acid glycoprotein	1
Asialofetuin	0
Asialo-[alpha]1-acid glycoprotein	0
Bovine submaxillary mucin	0
Ovine submaxillary mucin	0

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Biochem. J. 2003-07-01 ;373(Pt 2):369-79.

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

Montiel MD. et al. PMID:12678917

Cancer Res. 1989-12-01 ;49(23):6466-70.

Expression of UDP-GalNAc:NeuAc alpha 2,3Gal beta-R beta 1,4(GalNAc to Gal) N-acetylgalactosaminyltransferase involved in the synthesis of Sda antigen in human large intestine and colorectal carcinomas.

Malagolini N. et al. PMID:2510926

colonileumkidneylarge intestinestomach

B4GALNT2

N-Acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Acceptor Substrates (Reference)

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

DONOR : UDP-GalNAc

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

Expression of UDP-GalNAc:NeuAc alpha 2,3Gal beta-R beta 1,4(GalNAc to Gal) N-acetylgalactosaminyltransferase involved in the synthesis of Sda antigen in human large intestine and colorectal carcinomas.

Gene Ontology