GGDB:

B4GALNT2はbeta-1,4-N-acetyl-galactosaminyltransferase 2をコードする。本酵素は、ドナー基質であるUDP-GalNAcから、アクセプター基質である(NeuAcα2-3)Gal-に、β1,4結合でGalNAcを転移し、Sda血液型抗原（GalNAcβ1-4(NeuAcα2-3)Galβ1-4GlcNAc- R )、あるいは、CAD 抗原(GalNAcβ1-4(NeuAcα2-3)Gal-)を合成する。この酵素は正常の消化管で高発現しており、がん化においてはメチル化によりエピジェネティックな発現抑制を受けることが知られている。

Keyword: CAD抗原 , Sda抗原

	UDP-GalNAc
JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR		JCGG-STR031529 GlyTouCan: G39040YX GlyCosmos Glycans: G39040YX

	UDP-GalNAc
JCGG-STR031358 GlyTouCan: G79536OW GlyCosmos Glycans: G79536OW		JCGG-STR031362 GlyTouCan: G10112QT GlyCosmos Glycans: G10112QT

	UDP-GalNAc
JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK		JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	UDP-GalNAc
JCGG-STR031609 GlyTouCan: G43761FR GlyCosmos Glycans: G43761FR		JCGG-STR031530

	UDP-GalNAc
JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR		JCGG-STR031529 GlyTouCan: G39040YX GlyCosmos Glycans: G39040YX

N-Acetylgalactosaminyltransferase

GGDB Symbol

B4GALNT2 Alias

Designation

beta 1,4 N-acetylgalactosaminyltransferase 2

Organism

Homo sapiens

GeneID

124872

HGNC

B4GALNT2 (24136)

mRNA

NM_153446

map

17q21.32

Protein

NP_703147

EC#

CAZy

GT12

GlyCosmos Glycogenes

B4GALNT2

OMIM

111730

Disease name

GDGDB

Human Protein Atlas

ENSG00000167080

Mus musculus

mRNA	NM_008081
Protein	NP_032107
MGI	41753

Biochem. J. 2003-07-01 ;373(Pt 2):369-79.

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

Montiel MD. et al. PMID:12678917 Refer to: Table 1

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR	UDP-GalNAc	JCGG-STR031529 GlyTouCan: G39040YX GlyCosmos Glycans: G39040YX

	JCGG-STR031358 GlyTouCan: G79536OW GlyCosmos Glycans: G79536OW	UDP-GalNAc	JCGG-STR031362 GlyTouCan: G10112QT GlyCosmos Glycans: G10112QT

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK	UDP-GalNAc	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	JCGG-STR031526 GlyTouCan: G64527IJ GlyCosmos Glycans: G64527IJ	UDP-GalNAc	JCGG-STR031620 GlyTouCan: G36502OW GlyCosmos Glycans: G36502OW

	JCGG-STR031609 GlyTouCan: G43761FR GlyCosmos Glycans: G43761FR	UDP-GalNAc	JCGG-STR031530

	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR	UDP-GalNAc	JCGG-STR031529 GlyTouCan: G39040YX GlyCosmos Glycans: G39040YX

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE	UDP-GalNAc	JCGG-STR031531 GlyTouCan: G42797SX GlyCosmos Glycans: G42797SX

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO	UDP-GalNAc	JCGG-STR031618 GlyTouCan: G52935RP GlyCosmos Glycans: G52935RP

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	UDP-GalNAc	JCGG-STR031619 GlyTouCan: G31894FR GlyCosmos Glycans: G31894FR

Substrate Not Transferred

	JCGG-STR027263 GlyTouCan: G20044TD GlyCosmos Glycans: G20044TD

	JCGG-STR025461 GlyTouCan: G68639CF GlyCosmos Glycans: G68639CF

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR031360 GlyTouCan: G43804GS GlyCosmos Glycans: G43804GS

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK

	JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH

	JCGG-STR031354 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI

table 1
Glycoprotein	Enzyme activity
Fetuin	2
[alpha]1-acid glycoprotein	1
Asialofetuin	0
Asialo-[alpha]1-acid glycoprotein	0
Bovine submaxillary mucin	0
Ovine submaxillary mucin	0

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Biochem. J. 2003-07-01 ;373(Pt 2):369-79.

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

Montiel MD. et al. PMID:12678917

Cancer Res. 1989-12-01 ;49(23):6466-70.

Expression of UDP-GalNAc:NeuAc alpha 2,3Gal beta-R beta 1,4(GalNAc to Gal) N-acetylgalactosaminyltransferase involved in the synthesis of Sda antigen in human large intestine and colorectal carcinomas.

Malagolini N. et al. PMID:2510926

colonileumkidneylarge intestinestomach

B4GALNT2

N-Acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Acceptor Substrates (Reference)

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

DONOR : UDP-GalNAc

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

Expression of UDP-GalNAc:NeuAc alpha 2,3Gal beta-R beta 1,4(GalNAc to Gal) N-acetylgalactosaminyltransferase involved in the synthesis of Sda antigen in human large intestine and colorectal carcinomas.

Gene Ontology