GGDB:

β1,4-N-acetylgalactosaminyltransferase-III (B4GALNT3) transfers GalNAc from UDP-GalNAc to GlcNAcβ-R, synthesizing N,N'-diacetyllactosamine, GalNAcβ1→4GlcNAc (LacdiNAc) on N- and O-glycans. B4GALNT3 is also known as B4GalNac-T3. LacdiNAc structures are also synthesized by its homologue B4GALNT4, and occur on various glycoproteins including lutropin (LH), thyrotropin (TSH), zona pellucida 3 (ZP3), and extracellular matrix glycoproteins. LDN can be further modified with sulfation, sialylation, and fucosylation, indicating important roles of LacdiNAc structures in vivo.

Keyword:

	UDP-GalNAc
JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO		JCGG-STR029533 GlyTouCan: G00057MO GlyCosmos Glycans: G00057MO

N-Acetylgalactosaminyltransferase

GGDB Symbol

B4GALNT3 Alias

Designation

beta 1,4 N-acetylgalactosaminyltransferase 3

Organism

Homo sapiens

GeneID

283358

HGNC

B4GALNT3 (24137)

mRNA

NM_173593

map

12p13.33

Protein

NP_775864

EC#

CAZy

GlyCosmos Glycogenes

B4GALNT3

OMIM

612220

Disease name

GDGDB

Human Protein Atlas

ENSG00000139044

Mus musculus

mRNA	NM_198884
Protein	NP_094510
MGI	105577

Rattus norvegicus

mRNA	XM_575655
Protein	XP_575655

J. Biol. Chem. 2003-11-01 ;278(48):47534-44.

Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.

Sato T. et al. PMID:12966086 Refer to: TABLE II Table III, IV (A S), Fig. 7 (qRT-PCR)

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR015955 GlyTouCan: G00041MO GlyCosmos Glycans: G00041MO	UDP-GalNAc	JCGG-STR031590 GlyTouCan: G45849QU GlyCosmos Glycans: G45849QU

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-GalNAc	JCGG-STR029533 GlyTouCan: G00057MO GlyCosmos Glycans: G00057MO

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-GalNAc	JCGG-STR029533 GlyTouCan: G00057MO GlyCosmos Glycans: G00057MO

	JCGG-STR025794 GlyTouCan: G00035MO GlyCosmos Glycans: G00035MO	UDP-GalNAc	JCGG-STR031589 GlyTouCan: G35179MW GlyCosmos Glycans: G35179MW

	JCGG-STR029201 GlyTouCan: G00033MO GlyCosmos Glycans: G00033MO	UDP-GalNAc	JCGG-STR031588 GlyTouCan: G52144RR GlyCosmos Glycans: G52144RR

Substrate Not Transferred

	JCGG-STR008690 GlyTouCan: G68544GH GlyCosmos Glycans: G68544GH

	JCGG-STR032526 GlyTouCan: G09546QO GlyCosmos Glycans: G09546QO

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR008362 GlyTouCan: G61418DU GlyCosmos Glycans: G61418DU

	JCGG-STR032525 GlyTouCan: G58161NS GlyCosmos Glycans: G58161NS

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF

	JCGG-STR031580 GlyTouCan: G93723GS GlyCosmos Glycans: G93723GS

	JCGG-STR032134 GlyTouCan: G96881BQ GlyCosmos Glycans: G96881BQ

	JCGG-STR032527 GlyTouCan: G61491DK GlyCosmos Glycans: G61491DK

	JCGG-STR031571 GlyTouCan: G16579HJ GlyCosmos Glycans: G16579HJ

	JCGG-STR031571 GlyTouCan: G16579HJ GlyCosmos Glycans: G16579HJ

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2003-11-01 ;278(48):47534-44.

Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.

Sato T. et al. PMID:12966086

adrenal glandsaortabone marrowbraincolonfetal brainfetal kidneyfetal thyroid glandkidneylymph nodemammary glandovarypancreasplacentasalivary glandskeletal musclesmall intestinespleenstomachtestisthymusthyroid glandtracheauterus

B4GALNT3

N-Acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.

DONOR : UDP-GalNAc

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.

Gene Ontology