GGDB:

β1,4-N-acetylgalactosaminyltransferase-III (B4GALNT3)はUDP-GalNAcのGalNAcをGlcNAcβ-Rに転移しN-およびO-グリカン上のN,N'-diacetyllactosamine, GalNAcβ1→4GlcNAc (LacdiNAc)を合成する。B4GALNT3はB4GalNac-T3としても知られる。LacdiNAc構造は相同体であるB4GALNT4によっても合成され、ルトロピン（LH）、サイロトロピン（TSH）、zona pellucida 3（ZP3）を含む様々な糖タンパク質および細胞外基質糖タンパク質で起こる。LDNはさらに硫酸化、シアリル化、およびフコシル化で修飾を受けLacdiNAc構造の生体内での重要性を示している。

Keyword:

	UDP-GalNAc
JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO		JCGG-STR029533 GlyTouCan: G00057MO GlyCosmos Glycans: G00057MO

N-Acetylgalactosaminyltransferase

GGDB Symbol

B4GALNT3 Alias

Designation

beta 1,4 N-acetylgalactosaminyltransferase 3

Organism

Homo sapiens

GeneID

283358

HGNC

B4GALNT3 (24137)

mRNA

NM_173593

map

12p13.33

Protein

NP_775864

EC#

CAZy

GlyCosmos Glycogenes

B4GALNT3

OMIM

612220

Disease name

GDGDB

Human Protein Atlas

ENSG00000139044

Mus musculus

mRNA	NM_198884
Protein	NP_094510
MGI	105577

Rattus norvegicus

mRNA	XM_575655
Protein	XP_575655

J. Biol. Chem. 2003-11-01 ;278(48):47534-44.

Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.

Sato T. et al. PMID:12966086 Refer to: TABLE II Table III, IV (A S), Fig. 7 (qRT-PCR)

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR015955 GlyTouCan: G00041MO GlyCosmos Glycans: G00041MO	UDP-GalNAc	JCGG-STR031590 GlyTouCan: G45849QU GlyCosmos Glycans: G45849QU

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-GalNAc	JCGG-STR029533 GlyTouCan: G00057MO GlyCosmos Glycans: G00057MO

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-GalNAc	JCGG-STR029533 GlyTouCan: G00057MO GlyCosmos Glycans: G00057MO

	JCGG-STR025794 GlyTouCan: G00035MO GlyCosmos Glycans: G00035MO	UDP-GalNAc	JCGG-STR031589 GlyTouCan: G35179MW GlyCosmos Glycans: G35179MW

	JCGG-STR029201 GlyTouCan: G00033MO GlyCosmos Glycans: G00033MO	UDP-GalNAc	JCGG-STR031588 GlyTouCan: G52144RR GlyCosmos Glycans: G52144RR

Substrate Not Transferred

	JCGG-STR008690 GlyTouCan: G68544GH GlyCosmos Glycans: G68544GH

	JCGG-STR032526 GlyTouCan: G09546QO GlyCosmos Glycans: G09546QO

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR008362 GlyTouCan: G61418DU GlyCosmos Glycans: G61418DU

	JCGG-STR032525 GlyTouCan: G58161NS GlyCosmos Glycans: G58161NS

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF

	JCGG-STR031580 GlyTouCan: G93723GS GlyCosmos Glycans: G93723GS

	JCGG-STR032134 GlyTouCan: G96881BQ GlyCosmos Glycans: G96881BQ

	JCGG-STR032527 GlyTouCan: G61491DK GlyCosmos Glycans: G61491DK

	JCGG-STR031571 GlyTouCan: G16579HJ GlyCosmos Glycans: G16579HJ

	JCGG-STR031571 GlyTouCan: G16579HJ GlyCosmos Glycans: G16579HJ

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2003-11-01 ;278(48):47534-44.

Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.

Sato T. et al. PMID:12966086

adrenal glandsaortabone marrowbraincolonfetal brainfetal kidneyfetal thyroid glandkidneylymph nodemammary glandovarypancreasplacentasalivary glandskeletal musclesmall intestinespleenstomachtestisthymusthyroid glandtracheauterus

B4GALNT3

N-Acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.

DONOR : UDP-GalNAc

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.

Gene Ontology