GGDB:

GCNT3 is a glucosaminyl (N-acetyl) transferase 3, mucin type, which transfers GlcNAc from UDP-GlcNAc to the C6 position of GalNAc in core 1 and core 3 O-glycan structures, synthesizing core 2 and core 4 structures, respectively. GCNT3 also has a weak activity to form I-branching structure in vitro and on cell surface. GCNT3 is also known as C2GNT2, C2/4GNT, or C2GNT-M.

Keyword: I-branching , O-glycan , core 2 , core 4 , mucin

	UDP-GlcNAc
JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO		JCGG-STR029201 GlyTouCan: G00033MO GlyCosmos Glycans: G00033MO

	UDP-GlcNAc
JCGG-STR025794 GlyTouCan: G00035MO GlyCosmos Glycans: G00035MO		JCGG-STR022149 GlyTouCan: G00037MO GlyCosmos Glycans: G00037MO

	UDP-GlcNAc
JCGG-STR026619 GlyTouCan: G29487JS GlyCosmos Glycans: G29487JS		JCGG-STR007577 GlyTouCan: G08872UM GlyCosmos Glycans: G08872UM

N-Acetylglucosaminyltransferase

GGDB Symbol

GCNT3 Alias

Designation

glucosaminyl (N-acetyl) transferase 3, mucin type

Organism

Homo sapiens

GeneID

9245

HGNC

GCNT3 (4205)

mRNA

NM_004751

map

15q21.3

Protein

NP_004742

EC#

CAZy

GT14

GlyCosmos Glycogenes

GCNT3

OMIM

606836

Disease name

GDGDB

Human Protein Atlas

ENSG00000140297

Mus musculus

mRNA	NM_028087
Protein	NP_082363
MGI	56057

Rattus norvegicus

mRNA	NM_173312
Protein	NP_775434

J. Biol. Chem. 1999-01-01 ;274(5):3215-21.

Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches.

Yeh JC. et al. PMID:9915862 Refer to: FIG. 4. Fig. 4

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	UDP-GlcNAc	JCGG-STR029201 GlyTouCan: G00033MO GlyCosmos Glycans: G00033MO

	JCGG-STR025794 GlyTouCan: G00035MO GlyCosmos Glycans: G00035MO	UDP-GlcNAc	JCGG-STR022149 GlyTouCan: G00037MO GlyCosmos Glycans: G00037MO

	JCGG-STR027203 GlyTouCan: G82440PA GlyCosmos Glycans: G82440PA	UDP-GlcNAc	JCGG-STR032571 GlyTouCan: G44848DV GlyCosmos Glycans: G44848DV

	JCGG-STR032532 GlyTouCan: G00887EN GlyCosmos Glycans: G00887EN	UDP-GlcNAc	JCGG-STR032572 GlyTouCan: G79351OB GlyCosmos Glycans: G79351OB

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	UDP-GlcNAc	JCGG-STR029201 GlyTouCan: G00033MO GlyCosmos Glycans: G00033MO

	JCGG-STR025794 GlyTouCan: G00035MO GlyCosmos Glycans: G00035MO	UDP-GlcNAc	JCGG-STR022149 GlyTouCan: G00037MO GlyCosmos Glycans: G00037MO

	JCGG-STR026619 GlyTouCan: G29487JS GlyCosmos Glycans: G29487JS	UDP-GlcNAc	JCGG-STR007577 GlyTouCan: G08872UM GlyCosmos Glycans: G08872UM

J. Biol. Chem. 1999-02-01 ;274(8):4504-12.

Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4.

Schwientek T. et al. PMID:9988682 Refer to: TABLE I Table I

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	UDP-GlcNAc	JCGG-STR029201 GlyTouCan: G00033MO GlyCosmos Glycans: G00033MO

	JCGG-STR025794 GlyTouCan: G00035MO GlyCosmos Glycans: G00035MO	UDP-GlcNAc	JCGG-STR022149 GlyTouCan: G00037MO GlyCosmos Glycans: G00037MO

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	UDP-GlcNAc	JCGG-STR029201 GlyTouCan: G00033MO GlyCosmos Glycans: G00033MO

	JCGG-STR025794 GlyTouCan: G00035MO GlyCosmos Glycans: G00035MO	UDP-GlcNAc	JCGG-STR022149 GlyTouCan: G00037MO GlyCosmos Glycans: G00037MO

Substrate Not Transferred

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR004754 GlyTouCan: G33476GF GlyCosmos Glycans: G33476GF

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 1999-01-01 ;274(5):3215-21.

Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches.

Yeh JC. et al. PMID:9915862

J. Biol. Chem. 1999-02-01 ;274(8):4504-12.

Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4.

Schwientek T. et al. PMID:9988682

colonkidneypancreasprostatesmall intestinespleenstomachtestisthymusthyroid glandtrachea

Provided by GOA

Function
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

Process
O-glycan processing
carbohydrate metabolic process
immunoglobulin production in mucosal tissue
intestinal absorption
kidney morphogenesis
protein O-linked glycosylation
tissue morphogenesis

Component
Golgi membrane
extracellular exosome
integral component of membrane
membrane

GCNT3

N-Acetylglucosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches.

DONOR : UDP-GlcNAc

Substrate Transferred

Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4.

DONOR : UDP-GlcNAc

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches.

Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4.

Gene Ontology