Last Update:2022-01-07

OGT encodes an O-linked N-acetylglucosamine (GlcNAc) transferase, which transfers GlcNAc directly to Ser or Thr of proteins using UDP-GlcNAc as a donor substrate. GlcNAc modification by OGT is performed in the nucleus and cytoplasm, unlike the general glycosylation performed in the Golgi apparatus. Therefore, the substrates of OGT are nuclear and cytoplasmic proteins, and this reaction competes with phosphorylation. O-GlcNAc modification is a reversible reaction, and the added GlcNAc is removed by O-GlcNAc hydrolase (OGA). O-GlcNAc modification is involved in various cellular functions such as transcription and signal transduction, including the regulation of phosphorylation.

Keyword: O-GlcNAc ,  OGT


GGDB Symbol OGT    Alias
DesignationO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
OrganismHomo sapiens
GeneID 8473
HGNC OGT (8127)
mRNA NM_181673
Protein NP_858059
CAZy GT41   
GlyCosmos Glycogenes OGT
OMIM 300255
Disease name
Human Protein Atlas ENSG00000147162
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)


RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "OGT".