B3GNT2

Last Update:2017-03-27

β3GnT2 (B3GNT2) transfers GlcNAc to the N-acetyllactosamine structure [LacNAc: Galβ1-4GlcNAc]. By further elongating, poly-N-acetyllactosamine (polylactosamine, [Galβ1-4GlcNAc]n), which is a structure in which the N-acetyllactosamine structure is repeated, is biosynthesized. In in vitro analysis, β3GnT2 has a very strong enzyme activity against the polylactosamine structure, and it suggests that β3GnT2 is the main polylactosamine synthase.

Keyword: poly-N-acetyllactosamine , polylactosamine

	UDP-GlcNAc
JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO		JCGG-STR026619 GlyTouCan: G29487JS GlyCosmos Glycans: G29487JS

N-Acetylglucosaminyltransferase

GGDB Symbol

B3GNT2 Alias

Designation

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Organism

Homo sapiens

GeneID

HGNC

B3GNT2 (15629)

mRNA

map

2p15

Protein

EC#

2.4.1.149

CAZy

GT31

GlyCosmos Glycogenes

B3GNT2

OMIM

605581

Disease name

GDGDB

Human Protein Atlas

ENSG00000170340

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Orthologous Gene

Mus musculus

mRNA	NM_016888
Protein	NP_058584

Rattus norvegicus

mRNA	XM_223674
Protein	XP_223674

Acceptor Substrates (Reference)

FEBS Lett. 2001-02-01 ;276(5):3498-507.

Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.

Shiraishi N. et al. PMID:11042166 Refer to: Table 3,Table 4,Fig 4

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR032158 GlyTouCan: G84034JH GlyCosmos Glycans: G84034JH	UDP-GlcNAc	JCGG-STR013266 GlyTouCan: G91404LJ GlyCosmos Glycans: G91404LJ

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	UDP-GlcNAc	JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	UDP-GlcNAc	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	UDP-GlcNAc	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW

	JCGG-STR031377 GlyTouCan: G78941GA GlyCosmos Glycans: G78941GA	UDP-GlcNAc	JCGG-STR031636 GlyTouCan: G68257ZA GlyCosmos Glycans: G68257ZA

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO	UDP-GlcNAc	JCGG-STR031635 GlyTouCan: G97033IB GlyCosmos Glycans: G97033IB

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	UDP-GlcNAc	JCGG-STR026619 GlyTouCan: G29487JS GlyCosmos Glycans: G29487JS

Substrate Not Transferred

	JCGG-STR027035 GlyTouCan: G72002FC GlyCosmos Glycans: G72002FC

	JCGG-STR007014 GlyTouCan: G26123AX GlyCosmos Glycans: G26123AX

	JCGG-STR031387 GlyTouCan: G60629OV GlyCosmos Glycans: G60629OV

Proc. Natl. Acad. Sci. U.S.A. 2001-06-01 ;276(25):22032-40.

Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids.

Togayachi A. et al. PMID:11283017 Refer to: Table II,III

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	UDP-GlcNAc	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW

	JCGG-STR014685 GlyTouCan: G00058MO GlyCosmos Glycans: G00058MO	UDP-GlcNAc	JCGG-STR023826 GlyTouCan: G73480MV GlyCosmos Glycans: G73480MV

	JCGG-STR027037 GlyTouCan: G03362PH GlyCosmos Glycans: G03362PH	UDP-GlcNAc	JCGG-STR032529

	JCGG-STR027036 GlyTouCan: G46055MA GlyCosmos Glycans: G46055MA	UDP-GlcNAc	JCGG-STR032528 GlyTouCan: G25181AD GlyCosmos Glycans: G25181AD

	JCGG-STR031350 GlyTouCan: G60687RJ GlyCosmos Glycans: G60687RJ	UDP-GlcNAc	JCGG-STR032531 GlyTouCan: G81934BB GlyCosmos Glycans: G81934BB

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	UDP-GlcNAc	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW

Substrate Not Transferred

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

Proc. Natl. Acad. Sci. U.S.A. 2005-01-01 ;579(1):71-8.

A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer.

Ishida H. et al. PMID:15620693 Refer to: Table II, Figure 3 Table II,Figure 3

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR009367 GlyTouCan: G18938DW GlyCosmos Glycans: G18938DW	UDP-GlcNAc	JCGG-STR003947 GlyTouCan: G79431NA GlyCosmos Glycans: G79431NA

	JCGG-STR008928 GlyTouCan: G29857RC GlyCosmos Glycans: G29857RC	UDP-GlcNAc	JCGG-STR003944 GlyTouCan: G10599NM GlyCosmos Glycans: G10599NM

	JCGG-STR013729 GlyTouCan: G78059CC GlyCosmos Glycans: G78059CC	UDP-GlcNAc	JCGG-STR000310 GlyTouCan: G22865RK GlyCosmos Glycans: G22865RK

Substrate Not Transferred

	JCGG-STR002675 GlyTouCan: G86357DX GlyCosmos Glycans: G86357DX

	JCGG-STR003679 GlyTouCan: G63889NK GlyCosmos Glycans: G63889NK

	JCGG-STR028882 GlyTouCan: G22768VO GlyCosmos Glycans: G22768VO

	JCGG-STR008820 GlyTouCan: G36191CD GlyCosmos Glycans: G36191CD

Proc. Natl. Acad. Sci. U.S.A. 2008-11-01 ;283(48):33094-100.

Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells.

Seko A. et al. PMID:18826941

Proc. Natl. Acad. Sci. U.S.A. 1999-01-01 ;96(2):406-11.

A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases.

Zhou D. et al. PMID:9892646 Refer to: Table 1.

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	UDP-GlcNAc	JCGG-STR026619 GlyTouCan: G29487JS GlyCosmos Glycans: G29487JS

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	UDP-GlcNAc	JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	UDP-GlcNAc	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	UDP-GlcNAc	JCGG-STR026619 GlyTouCan: G29487JS GlyCosmos Glycans: G29487JS

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	UDP-GlcNAc	JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	UDP-GlcNAc	JCGG-STR026619 GlyTouCan: G29487JS GlyCosmos Glycans: G29487JS

Substrate Not Transferred

	JCGG-STR008690 GlyTouCan: G68544GH GlyCosmos Glycans: G68544GH

	JCGG-STR032526 GlyTouCan: G09546QO GlyCosmos Glycans: G09546QO

	JCGG-STR008362 GlyTouCan: G61418DU GlyCosmos Glycans: G61418DU

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR025794 GlyTouCan: G00035MO GlyCosmos Glycans: G00035MO

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR008362 GlyTouCan: G61418DU GlyCosmos Glycans: G61418DU

	JCGG-STR008690 GlyTouCan: G68544GH GlyCosmos Glycans: G68544GH

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR032526 GlyTouCan: G09546QO GlyCosmos Glycans: G09546QO

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR008690 GlyTouCan: G68544GH GlyCosmos Glycans: G68544GH

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

Acceptor Substrates (KEM-C)

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

		UDP-GlcNAc
	JCGG-STR025848 GlyTouCan: G64973KT GlyCosmos Glycans: G64973KT		JCGG-STR031449 GlyTouCan: G97494HI GlyCosmos Glycans: G97494HI

		UDP-GlcNAc
	JCGG-STR027300 GlyTouCan: G32723SL GlyCosmos Glycans: G32723SL		JCGG-STR004435 GlyTouCan: G23438NR GlyCosmos Glycans: G23438NR

		UDP-GlcNAc
	JCGG-STR004557 GlyTouCan: G19749DC GlyCosmos Glycans: G19749DC		JCGG-STR031486 GlyTouCan: G72734AU GlyCosmos Glycans: G72734AU

Substrate Not Transferred


	JCGG-STR027483 GlyTouCan: G11457RF GlyCosmos Glycans: G11457RF


	JCGG-STR027221 GlyTouCan: G17752YB GlyCosmos Glycans: G17752YB


	JCGG-STR008757 GlyTouCan: G41245OZ GlyCosmos Glycans: G41245OZ


	JCGG-STR031464 GlyTouCan: G64844ET GlyCosmos Glycans: G64844ET

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

FEBS Lett. 2001-02-01 ;276(5):3498-507.

Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.

Shiraishi N. et al. PMID:11042166

Proc. Natl. Acad. Sci. U.S.A. 1999-01-01 ;96(2):406-11.

A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases.

Zhou D. et al. PMID:9892646

adrenal glandsbraincolonfetal brainfetal kidneyfetal liverfetal lungheartkidneyliverlunglymph nodemammary glandpancreaspituitary glandplacentaprostatesalivary glandskeletal musclesmall intestinespinal cordspleenstomachtestisthymusthyroid glandtracheauterus

Gene Ontology

Provided by GOA

Function
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

Process
O-glycan processing
axon guidance
keratan sulfate biosynthetic process
keratan sulfate synthesis
poly-N-acetyllactosamine biosynthetic process
sensory perception of smell

Component
Golgi membrane
extracellular exosome
integral component of membrane

This page does not indicate all of the enzymatic reaction, and expression of "B3GNT2".