GGDB:

β3GnT4 (B3GNT4) transfers GlcNAc to the N-acetyllactosamine structure [LacNAc: Galβ1-4GlcNAc]. By further elongating, the poly-N-acetyllactosamine (polylactosamine, [Galβ1-4GlcNAc]n), which has a repeating structure of the N-acetyllactosamine structure, is biosynthesized.

Keyword: poly-N-acetyllactosamine , polylactosamine

	UDP-GlcNAc
JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO		JCGG-STR026619 GlyTouCan: G29487JS GlyCosmos Glycans: G29487JS

N-Acetylglucosaminyltransferase

GGDB Symbol

B3GNT4 Alias

Designation

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4

Organism

Homo sapiens

GeneID

79369

HGNC

B3GNT4 (15683)

mRNA

NM_030765

map

12q24

Protein

NP_110392

EC#

2.4.1.149

CAZy

GT31

GlyCosmos Glycogenes

B3GNT4

OMIM

605864

Disease name

GDGDB

Human Protein Atlas

ENSG00000176383

Mus musculus

mRNA	NM_198611
Protein	NP_941013
MGI	93771

Rattus norvegicus

mRNA	NM_222292
Protein	XP_222292

J. Biol. Chem. 2001-02-01 ;276(5):3498-507.

Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.

Shiraishi N. et al. PMID:11042166 Refer to: Table 3,Table 4,Fig 4

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	UDP-GlcNAc	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	UDP-GlcNAc	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	UDP-GlcNAc	JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	UDP-GlcNAc	JCGG-STR026619 GlyTouCan: G29487JS GlyCosmos Glycans: G29487JS

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO	UDP-GlcNAc	JCGG-STR031635 GlyTouCan: G97033IB GlyCosmos Glycans: G97033IB

	JCGG-STR031377 GlyTouCan: G78941GA GlyCosmos Glycans: G78941GA	UDP-GlcNAc	JCGG-STR031636 GlyTouCan: G68257ZA GlyCosmos Glycans: G68257ZA

Substrate Not Transferred

	JCGG-STR027035 GlyTouCan: G72002FC GlyCosmos Glycans: G72002FC

	JCGG-STR007014 GlyTouCan: G26123AX GlyCosmos Glycans: G26123AX

	JCGG-STR031387 GlyTouCan: G60629OV GlyCosmos Glycans: G60629OV

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR032158 GlyTouCan: G84034JH GlyCosmos Glycans: G84034JH

J. Biol. Chem. 2001-06-01 ;276(25):22032-40.

Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids.

Togayachi A. et al. PMID:11283017 Refer to: Table II,Table III

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Not Transferred

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

	JCGG-STR014685 GlyTouCan: G00058MO GlyCosmos Glycans: G00058MO

	JCGG-STR027036 GlyTouCan: G46055MA GlyCosmos Glycans: G46055MA

	JCGG-STR027037 GlyTouCan: G03362PH GlyCosmos Glycans: G03362PH

	JCGG-STR031350 GlyTouCan: G60687RJ GlyCosmos Glycans: G60687RJ

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2001-02-01 ;276(5):3498-507.

Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.

Shiraishi N. et al. PMID:11042166

braincolonfetal brainkidney

B3GNT4

N-Acetylglucosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.

DONOR : UDP-GlcNAc

Substrate Transferred

Substrate Not Transferred

Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids.

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.

Gene Ontology