B3GNT6

Last Update:2021-12-03

B3GNT6 encodes UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6. This enzyme uses GalNAc alpha- as an acceptor substrate and transfers GlcNAc with a beta1,3 linkage to synthesize GlcNAc beta1,3GalNAc alpha-, which is known as core 3 structure of O-glycan. The B3GNT6 gene is expressed mainly in goblet cells of colon in human and is thought to be related to the O-linked glycosylation of gastrointestinal mucins. B3GNT6 gene expression is lost upon tumorigenesis. In mouse model, high expression of B3GNT6 inhibited the metastatic potential of cancer cells, suggesting that B3GNT6 may have a function related to cancer malignancy.

Keyword: O-glycan ,  core 3 ,  mucin

UDP-GlcNAc
JCGG-STR025718
GlyTouCan: G57321FI
GlyCosmos Glycans: G57321FI
JCGG-STR025794
GlyTouCan: G00035MO
GlyCosmos Glycans: G00035MO

N-Acetylglucosaminyltransferase


GGDB Symbol B3GNT6    Alias
DesignationUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
OrganismHomo sapiens
GeneID 192134
HGNC B3GNT6 (24141)
mRNA NM_138706
map11q13.4
Protein NP_619651
EC# 2.4.1.149   
CAZy GT31   
GlyCosmos Glycogenes B3GNT6
OMIM 615315
Disease name
GDGDB
Human Protein Atlas ENSG00000198488
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "B3GNT6".