B3GNT8 encodes UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8. This enzyme transfer GlcNAc toward Gal at the non-reducing end of four-branched N-glycans in vitro. This enzyme has weak activity toward the N-acetyllactosamine structure (LacNAc: Gal beta 1-4GlcNAc). β3GnT8 has been reported to form a complex with β3GnT2, and this complex has strong polylactosamine synthesis activity against four-branched N-glycans. It is also known that the expression of B3GNT8 gene is significantly up-regulated in colon cancer tissues compared to normal tissues.
Keyword:
poly-N-acetyllactosamine
, polylactosamine
, tetraanntennary N-glycan
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JCGG-STR009367
GlyTouCan:
G18938DW
GlyCosmos Glycans:
G18938DW
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JCGG-STR031639
GlyTouCan:
G66098KC
GlyCosmos Glycans:
G66098KC
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JCGG-STR003679
GlyTouCan:
G63889NK
GlyCosmos Glycans:
G63889NK
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JCGG-STR031640
GlyTouCan:
G88966ZO
GlyCosmos Glycans:
G88966ZO
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N-Acetylglucosaminyltransferase
| B3GNT8 Alias | |
| Designation | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 |
| Organism | Homo sapiens |
| GeneID | 374907 |
| HGNC | B3GNT8 (24139) |
| mRNA | AB175895 |
| map | 19q13.2 |
| Protein | BAD86525 |
| EC# | |
| CAZy | |
| GlyCosmos Glycogenes | B3GNT8 |
| OMIM | 615357 |
| GDGDB | |
| Human Protein Atlas | ENSG00000177191 |
Mus musculus
Rattus norvegicus
