GGDB:

A4GNTはalpha-1,4-N-acetylglucosaminyltransferaseをコードする。A4GNTはO結合型糖鎖に含まれるGalβ-をアクセプター基質として、GlcNAcをα1,4結合で転移し、GlcNAcα1,4Gal-を合成する。この糖鎖は、胃から分泌される腺粘液に含まれるムチン糖タンパク質上に存在し、ヘリコバクターピロリ菌の増殖を抑制する働きがあることが知られている。

Keyword: O結合型糖鎖 , αGlcNAc , ヘリコバクターピロリ , 線粘液 , 胃

	(not applicable)
JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE		JCGG-STR031621 GlyTouCan: G94473FP GlyCosmos Glycans: G94473FP

N-Acetylglucosaminyltransferase

GGDB Symbol

A4GNT Alias

Designation

alpha-1,4-N-acetylglucosaminyltransferase

Organism

Homo sapiens

GeneID

51146

HGNC

A4GNT (17968)

mRNA

NM_016161

map

3p14.3

Protein

NP_057245

EC#

CAZy

GlyCosmos Glycogenes

A4GNT

OMIM

616709

Disease name

GDGDB

Human Protein Atlas

ENSG00000118017

Mus musculus

mRNA	XM_286168
Protein	XP_286168
MGI	70701

Rattus norvegicus

mRNA	XM_236601
Protein	XP_236601

Proc. Natl. Acad. Sci. U.S.A. 1999-08-01 ;96(16):8991-6.

Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin.

Nakayama J. et al. PMID:10430883 Refer to: FIG. 5.

DONOR : (not applicable) UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025848 GlyTouCan: G64973KT GlyCosmos Glycans: G64973KT	UDP-GlcNAc	JCGG-STR003758 GlyTouCan: G34764BK GlyCosmos Glycans: G34764BK

	JCGG-STR029201 GlyTouCan: G00033MO GlyCosmos Glycans: G00033MO	UDP-GlcNAc	JCGG-STR031591 GlyTouCan: G27523II GlyCosmos Glycans: G27523II

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	UDP-GlcNAc	JCGG-STR031625 GlyTouCan: G55055JS GlyCosmos Glycans: G55055JS

	JCGG-STR023793 GlyTouCan: G10400UC GlyCosmos Glycans: G10400UC	UDP-GlcNAc	JCGG-STR031622 GlyTouCan: G44375VE GlyCosmos Glycans: G44375VE

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	UDP-GlcNAc	JCGG-STR031623 GlyTouCan: G37329VY GlyCosmos Glycans: G37329VY

	JCGG-STR025848 GlyTouCan: G64973KT GlyCosmos Glycans: G64973KT	UDP-GlcNAc	JCGG-STR031628 GlyTouCan: G32910OR GlyCosmos Glycans: G32910OR

	JCGG-STR025848 GlyTouCan: G64973KT GlyCosmos Glycans: G64973KT	UDP-GlcNAc	JCGG-STR031627 GlyTouCan: G39890DX GlyCosmos Glycans: G39890DX

	JCGG-STR031627 GlyTouCan: G39890DX GlyCosmos Glycans: G39890DX	UDP-GlcNAc	JCGG-STR003758 GlyTouCan: G34764BK GlyCosmos Glycans: G34764BK

	JCGG-STR031628 GlyTouCan: G32910OR GlyCosmos Glycans: G32910OR	UDP-GlcNAc	JCGG-STR003758 GlyTouCan: G34764BK GlyCosmos Glycans: G34764BK

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE	(not applicable)	JCGG-STR031621 GlyTouCan: G94473FP GlyCosmos Glycans: G94473FP

Substrate Not Transferred

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR025794 GlyTouCan: G00035MO GlyCosmos Glycans: G00035MO

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Proc. Natl. Acad. Sci. U.S.A. 1999-08-01 ;96(16):8991-6.

Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin.

Nakayama J. et al. PMID:10430883

pancreasstomach

A4GNT

N-Acetylglucosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin.

DONOR : (not applicable) UDP-GlcNAc

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin.

Gene Ontology