GGDB:

β1,4-N-Acetylglucosaminyltransferase-I (MGAT1)は、N-結合型糖鎖（Manα1-6(Manα1-3)Manα1-6(Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn）構造にβ1-2でGlcNAcを転移し、N-結合型糖鎖（Manα1-6(Manα1-3)Manα1-6(GlcNAcβ1-2Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn）構造を合成する酵素である。Mgat1欠損マウスは胎生致死である。

Keyword: GLCNAC-TI , GLCT1 , GLYT1 , GNT-I , GNT1 , MGAT

	UDP-GlcNAc
JCGG-STR014426 GlyTouCan: G55220VL GlyCosmos Glycans: G55220VL		JCGG-STR009334 GlyTouCan: G08520NM GlyCosmos Glycans: G08520NM

N-Acetylglucosaminyltransferase

GGDB Symbol

MGAT1 Alias

Designation

mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Organism

Homo sapiens

GeneID

4245

HGNC

MGAT1 (7044)

mRNA

NM_002406

map

5q35

Protein

NP_002397

EC#

2.4.1.101

CAZy

GT13

GlyCosmos Glycogenes

MGAT1

OMIM

160995

Disease name

GDGDB

Human Protein Atlas

ENSG00000131446

Mus musculus

mRNA	NM_010794
Protein	NP_034924
MGI	11235

Rattus norvegicus

mRNA	NM_030861
Protein	NP_110488

Caenorhabditis elegans

mRNA	NM_077165
Protein	NP_509566

Drosophila melanogaster

mRNA	NM_080378
Protein	NP_525117

Arabidopsis thaliana

mRNA	NM_119986
Protein	NP_195537

Proc. Natl. Acad. Sci. U.S.A. 2007-10-01 ;362(2):381-6.

Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121.

Saribas AS. et al. PMID:17716624 Refer to: Table 1

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR029451 GlyTouCan: G23046QV GlyCosmos Glycans: G23046QV	UDP-GlcNAc	JCGG-STR032538 GlyTouCan: G08301LT GlyCosmos Glycans: G08301LT

Biochem. Biophys. Res. Commun. 1991-01-01 ;88(1):234-8.

Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

Sarkar M. et al. PMID:1824724

Biochem. J. 1991-04-01 ;176(2):608-15.

Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene.

Hull E. et al. PMID:1827260

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR002707 GlyTouCan: G99858XP GlyCosmos Glycans: G99858XP	UDP-GlcNAc	JCGG-STR002696 GlyTouCan: G82942ZJ GlyCosmos Glycans: G82942ZJ

	JCGG-STR014426 GlyTouCan: G55220VL GlyCosmos Glycans: G55220VL	UDP-GlcNAc	JCGG-STR009334 GlyTouCan: G08520NM GlyCosmos Glycans: G08520NM

Biochem. J. 1997-01-01 ;321 ( Pt 2)():465-74.

Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.

Yip B. et al. PMID:9020882

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Biochem. Biophys. Res. Commun. 1991-01-01 ;88(1):234-8.

Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

Sarkar M. et al. PMID:1824724

Biochem. J. 1997-01-01 ;321 ( Pt 2)():465-74.

Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.

Yip B. et al. PMID:9020882

brainheartkidneyliverlungpancreasplacentaskeletal muscle

Provided by GOA

Function
acetylglucosaminyltransferase activity
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
metal ion binding

Process
UDP-N-acetylglucosamine catabolic process
carbohydrate metabolic process
in utero embryonic development
protein glycosylation

Component
Golgi membrane
extracellular exosome
extracellular vesicle
integral component of membrane
membrane

MGAT1

N-Acetylglucosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Arabidopsis thaliana

Acceptor Substrates (Reference)

Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121.

DONOR : UDP-GlcNAc

Substrate Transferred

Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene.

DONOR : UDP-GlcNAc

Substrate Transferred

Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.

Gene Ontology