GGDB:

β1,4-N-Acetylglucosaminyltransferase-I (MGAT1)は、N-結合型糖鎖（Manα1-6(Manα1-3)Manα1-6(Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn）構造にβ1-2でGlcNAcを転移し、N-結合型糖鎖（Manα1-6(Manα1-3)Manα1-6(GlcNAcβ1-2Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn）構造を合成する酵素である。Mgat1欠損マウスは胎生致死である。

Keyword: GLCNAC-TI , GLCT1 , GLYT1 , GNT-I , GNT1 , MGAT

	UDP-GlcNAc
JCGG-STR014426 GlyTouCan: G55220VL GlyCosmos Glycans: G55220VL		JCGG-STR009334 GlyTouCan: G08520NM GlyCosmos Glycans: G08520NM

N-Acetylglucosaminyltransferase

GGDB Symbol

MGAT1 Alias

Designation

mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Organism

Homo sapiens

GeneID

4245

HGNC

MGAT1 (7044)

mRNA

NM_002406

map

5q35

Protein

NP_002397

EC#

2.4.1.101

CAZy

GT13

GlyCosmos Glycogenes

MGAT1

OMIM

160995

Disease name

GDGDB

Human Protein Atlas

ENSG00000131446

Mus musculus

mRNA	NM_010794
Protein	NP_034924
MGI	11235

Rattus norvegicus

mRNA	NM_030861
Protein	NP_110488

Caenorhabditis elegans

mRNA	NM_077165
Protein	NP_509566

Drosophila melanogaster

mRNA	NM_080378
Protein	NP_525117

Arabidopsis thaliana

mRNA	NM_119986
Protein	NP_195537

Proc. Natl. Acad. Sci. U.S.A. 2007-10-01 ;362(2):381-6.

Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121.

Saribas AS. et al. PMID:17716624 Refer to: Table 1

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR029451 GlyTouCan: G23046QV GlyCosmos Glycans: G23046QV	UDP-GlcNAc	JCGG-STR032538 GlyTouCan: G08301LT GlyCosmos Glycans: G08301LT

Biochem. J. 1991-01-01 ;88(1):234-8.

Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

Sarkar M. et al. PMID:1824724

Biochem. J. 1991-04-01 ;176(2):608-15.

Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene.

Hull E. et al. PMID:1827260

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR002707 GlyTouCan: G99858XP GlyCosmos Glycans: G99858XP	UDP-GlcNAc	JCGG-STR002696 GlyTouCan: G82942ZJ GlyCosmos Glycans: G82942ZJ

	JCGG-STR014426 GlyTouCan: G55220VL GlyCosmos Glycans: G55220VL	UDP-GlcNAc	JCGG-STR009334 GlyTouCan: G08520NM GlyCosmos Glycans: G08520NM

Biochem. J. 1997-01-01 ;321 ( Pt 2)():465-74.

Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.

Yip B. et al. PMID:9020882

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Biochem. J. 1991-01-01 ;88(1):234-8.

Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

Sarkar M. et al. PMID:1824724

Biochem. J. 1997-01-01 ;321 ( Pt 2)():465-74.

Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.

Yip B. et al. PMID:9020882

brainheartkidneyliverlungpancreasplacentaskeletal muscle

Provided by GOA

Function
acetylglucosaminyltransferase activity
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
metal ion binding

Process
UDP-N-acetylglucosamine catabolic process
carbohydrate metabolic process
in utero embryonic development
protein glycosylation

Component
Golgi membrane
extracellular exosome
extracellular vesicle
integral component of membrane
membrane

MGAT1

N-Acetylglucosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Arabidopsis thaliana

Acceptor Substrates (Reference)

Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121.

DONOR : UDP-GlcNAc

Substrate Transferred

Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene.

DONOR : UDP-GlcNAc

Substrate Transferred

Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.

Gene Ontology