GGDB:

β1,4-N-Acetylglucosaminyltransferase-II (MGAT2) transfers GlcNAc to β1-2 of Manα1-6(GlcNAcβ1-2Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn, which is generated by mannosidase taking two mannoses from Manα1-6(Manα1-3)Manα1-6(GlcNAcβ1-2Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn synthesized by MGAT1, and synthesizes the GlcNAcb1-2Mana1-6(GlcNAcb1-2Mana1-3)Manb1-4GlcNAcb1-4GlcNAcb1-Asn structure. Mgat2-deficient mice show reduction of N-linked glycans including N-acetyllactosamine and result in lethality after birth.

Keyword: CDGS2 , GLCNACTII , GNT-II , GNT2

	UDP-GlcNAc
JCGG-STR009312 GlyTouCan: G61751GZ GlyCosmos Glycans: G61751GZ		JCGG-STR009224 GlyTouCan: G39213VZ GlyCosmos Glycans: G39213VZ

N-Acetylglucosaminyltransferase

GGDB Symbol

MGAT2 Alias

Designation

mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Organism

Homo sapiens

GeneID

4247

HGNC

MGAT2 (7045)

mRNA

NM_002408

map

14q21

Protein

NP_002399

EC#

2.4.1.143

CAZy

GT16

GlyCosmos Glycogenes

MGAT2

OMIM

602616

Disease name

CDG IIa , Congenital Disorder of Glycosylation type IIa

GDGDB

CON00358

Human Protein Atlas

ENSG00000168282

Mus musculus

mRNA	NM_146035
Protein	NP_666147
MGI	86979

Rattus norvegicus

mRNA	NM_053604
Protein	NP_446056

Caenorhabditis elegans

mRNA	NM_073463
Protein	NP_505864

Drosophila melanogaster

mRNA	NM_143506
Protein	NP_651763

Eur. J. Biochem. 1995-07-01 ;231(2):317-28.

The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein.

Tan J. et al. PMID:7635144

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR017411 GlyTouCan: G07483YN GlyCosmos Glycans: G07483YN	UDP-GlcNAc	JCGG-STR017422 GlyTouCan: G80858MF GlyCosmos Glycans: G80858MF

	JCGG-STR009312 GlyTouCan: G61751GZ GlyCosmos Glycans: G61751GZ	UDP-GlcNAc	JCGG-STR009224 GlyTouCan: G39213VZ GlyCosmos Glycans: G39213VZ

	JCGG-STR004522 GlyTouCan: G64272SY GlyCosmos Glycans: G64272SY	UDP-GlcNAc	JCGG-STR004555 GlyTouCan: G48524PJ GlyCosmos Glycans: G48524PJ

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Eur. J. Biochem. 1995-07-01 ;231(2):317-28.

The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein.

Tan J. et al. PMID:7635144

bloodbrainbreastcervixcoloneargerm cellsheartkidneyliverlunglymph nodemammary glandovarypancreasparathyroidplacentaprostateskeletal musclespleenstomachtestisthymustonsiluteruswhole embryo

Provided by GOA

Function
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
carbohydrate binding

Process
oligosaccharide biosynthetic process
oligosaccharide metabolic process
protein N-linked glycosylation
protein N-linked glycosylation via asparagine

Component
Golgi apparatus
Golgi membrane
Golgi stack
integral component of membrane
membrane

MGAT2

N-Acetylglucosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein.

DONOR : UDP-GlcNAc

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein.

Gene Ontology