GGDB:

β1,4-N-Acetylglucosaminyltransferase-III (MGAT3)は、MGAT2が合成した糖鎖構造（GlcNAcβ1-2Manα1-6(GlcNAcβ1-2Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn）構造に対して、β1-4でGlcNAcを転移し、bisecting GlcNAcと呼ばれる構造（GlcNAcβ1-2Manα1-6(GlcNAcβ1-2(GlcNAcβ1-4)Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn）を合成する。

Keyword: GNT-III , GNT3

	UDP-GlcNAc
JCGG-STR009224 GlyTouCan: G39213VZ GlyCosmos Glycans: G39213VZ		JCGG-STR013751 GlyTouCan: G59471TH GlyCosmos Glycans: G59471TH

N-Acetylglucosaminyltransferase

GGDB Symbol

MGAT3 Alias

Designation

mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

Organism

Homo sapiens

GeneID

4248

HGNC

MGAT3 (7046)

mRNA

NM_002409

map

22q13.1

Protein

NP_002400

EC#

2.4.1.144

CAZy

GT17

GlyCosmos Glycogenes

MGAT3

OMIM

604621

Disease name

GDGDB

Human Protein Atlas

ENSG00000128268

Mus musculus

mRNA	NM_010795
Protein	NP_034925
MGI	24685

Rattus norvegicus

mRNA	NM_019239
Protein	NP_062112

Drosophila melanogaster

mRNA	NM_165027
Protein	NP_723787

J. Biol. Chem. 1999-03-01 ;9(3):303-10.

Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N-acetylglucosaminyltransferase.

Yoshida A. et al. PMID:10024668

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR009224 GlyTouCan: G39213VZ GlyCosmos Glycans: G39213VZ	UDP-GlcNAc	JCGG-STR013751 GlyTouCan: G59471TH GlyCosmos Glycans: G59471TH

J. Biol. Chem. 1982-09-01 ;257(17):10235-42.

Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides.

Narasimhan S. et al. PMID:6213618

J. Biol. Chem. 1983-05-01 ;258(10):6162-73.

Control of glycoprotein synthesis.

Gleeson PA. et al. PMID:6222042 Refer to: TABLE III

DONOR : UDP-GlcNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR009224 GlyTouCan: G39213VZ GlyCosmos Glycans: G39213VZ	UDP-GlcNAc	JCGG-STR013751 GlyTouCan: G59471TH GlyCosmos Glycans: G59471TH

	JCGG-STR017422 GlyTouCan: G80858MF GlyCosmos Glycans: G80858MF	UDP-GlcNAc	JCGG-STR020897 GlyTouCan: G30159WR GlyCosmos Glycans: G30159WR

	JCGG-STR020757 GlyTouCan: G27919IH GlyCosmos Glycans: G27919IH	UDP-GlcNAc	JCGG-STR020768 GlyTouCan: G85767HW GlyCosmos Glycans: G85767HW

Substrate Not Transferred

	JCGG-STR017411 GlyTouCan: G07483YN GlyCosmos Glycans: G07483YN

	JCGG-STR002707 GlyTouCan: G99858XP GlyCosmos Glycans: G99858XP

	JCGG-STR020895 GlyTouCan: G58667NI GlyCosmos Glycans: G58667NI

	JCGG-STR013729 GlyTouCan: G78059CC GlyCosmos Glycans: G78059CC

	JCGG-STR014874 GlyTouCan: G77252PU GlyCosmos Glycans: G77252PU

J. Biol. Chem. 1993-06-01 ;113(6):692-8.

cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III).

Ihara Y. et al. PMID:8370666

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 1993-06-01 ;113(6):692-8.

cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III).

Ihara Y. et al. PMID:8370666

brainkidney

Provided by GOA

Function
beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

Process
protein N-linked glycosylation

Component
Golgi membrane
integral component of membrane

MGAT3

N-Acetylglucosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Drosophila melanogaster

Acceptor Substrates (Reference)

Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N-acetylglucosaminyltransferase.

DONOR : UDP-GlcNAc

Substrate Transferred

Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides.

Control of glycoprotein synthesis.

DONOR : UDP-GlcNAc

Substrate Transferred

Substrate Not Transferred

cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III).

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III).

Gene Ontology