RFNG |
Last Update:2022-01-07 |
RFNG encodes Radical Fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. Fringe (in mammals, there are Lunatic Fringe, Manic Fringe, and Radical Fringe) is a β1,3-N-acetylglucosaminyltransferase involved in the synthesis of O-linked fucose glycans in the EGF domain of Notch protein, and was discovered as a gene that causes a mutation in Drosophila melanogaster that results in abnormal dorsal-ventral boundary formation during feather formation. Fringe transfers GlcNAc toward O-fucose synthesized by POFUT1, are essential for the activation of Notch signalings through the ligands such as Delta and Serrate/Jagged.
RFNG Alias | |
Designation | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
Organism | Homo sapiens |
GeneID | 5986 |
HGNC | RFNG (9974) |
mRNA | AF108139 |
map | 17q25 |
Protein | Q9Y644 |
EC# | 2.4.1.222 |
CAZy | |
GlyCosmos Glycogenes | RFNG |
OMIM | 602578 |
GDGDB | |
Human Protein Atlas | ENSG00000169733 |
data available from v22.proteinatlas.org