Last Update:2022-01-07

RFNG encodes Radical Fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. Fringe (in mammals, there are Lunatic Fringe, Manic Fringe, and Radical Fringe) is a β1,3-N-acetylglucosaminyltransferase involved in the synthesis of O-linked fucose glycans in the EGF domain of Notch protein, and was discovered as a gene that causes a mutation in Drosophila melanogaster that results in abnormal dorsal-ventral boundary formation during feather formation. Fringe transfers GlcNAc toward O-fucose synthesized by POFUT1, are essential for the activation of Notch signalings through the ligands such as Delta and Serrate/Jagged.

Keyword: EGF domain ,  Notch ,  O-fucosylated glycan


GGDB Symbol RFNG    Alias
DesignationRFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
OrganismHomo sapiens
GeneID 5986
HGNC RFNG (9974)
mRNA AF108139
Protein Q9Y644
GlyCosmos Glycogenes RFNG
OMIM 602578
Disease name
Human Protein Atlas ENSG00000169733
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)


RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "RFNG".