Last Update:2021-12-17

HAS3 encodes hyaluronan synthase 3. Hyaluronan (HA) is a linear macromolecule composed of a disaccharide repeat of (GlcNAcβ1,4GlcAβ1,3)n and is a major component of the extracellular matrix. The hyaluronan-synthesizing glycosyltransferase, HAS, is a multiple transmembrane protein found in the plasma membrane. It performs the hyaluronan elongation reaction using UDP-GlcNAc and UDP-GlcA as donor substrates in the cytoplasmic catalytic region. In humans, there are three isoenzymes (HAS1, HAS2, and HAS3), each with different enzymatic properties, that synthesize hyaluronan of various degrees of polymerization with different molecular weights.

Keyword: Extracellular matrix ,  GlcA ,  GlcNAc ,  Hyaluronan

Glucuronyltransferase N-Acetylglucosaminyltransferase

GGDB Symbol HAS3    Alias
Designationhyaluronan synthase 3
OrganismHomo sapiens
GeneID 3038
HGNC HAS3 (4820)
mRNA NM_005329
Protein NP_005320
CAZy GT2   
GlyCosmos Glycogenes HAS3
OMIM 602428
Disease name
Human Protein Atlas ENSG00000103044
Open ALL Close ALL

Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)


RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "HAS3".