Last Update:2022-01-07

POMT1 encodes protein O-mannosyltransferase 1. POMT1 and POMT2 transfer Man to the hydroxyl group of Ser or Thr of specific proteins such as alpha-dystroglycan using mannose dolicholate as a sugar donor. POMT1 and POMT2 are multiple transmembrane proteins, respectively, and form a complex in the endoplasmic reticulum to exert enzymatic activities. Both POMT1 and POMT2 genes are known to be causative genes of Walker-Warburg syndrome, a congenital muscular dystrophy.



GGDB Symbol POMT1    Alias
Designationprotein O-mannosyl-transferase
OrganismHomo sapiens
GeneID 10585
HGNC POMT1 (9202)
mRNA NM_007171
Protein NP_009102
CAZy GT39   
GlyCosmos Glycogenes POMT1
OMIM 607423
Disease name
Human Protein Atlas ENSG00000130714
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)


RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "POMT1".