POMT2

Last Update:2022-01-07

POMT2 encodes protein O-mannosyltransferase 2. POMT1 and POMT2 transfer Man to the hydroxyl group of Ser or Thr of specific proteins such as alpha-dystroglycan using mannose dolicholate as a sugar donor. POMT1 and POMT2 are multiple transmembrane proteins, respectively, and form a complex in the endoplasmic reticulum to exert enzymatic activities. Both POMT1 and POMT2 genes are known to be causative genes of Walker-Warburg syndrome, a congenital muscular dystrophy.

Keyword:

Mannosyltransferases

GGDB Symbol

POMT2 Alias

Designation

putative protein O-mannosyl-transferase

Organism

Homo sapiens

GeneID

29954

HGNC

POMT2 (19743)

mRNA

NM_013382

map

14q24.3

Protein

NP_037514

EC#

2.4.1.109

CAZy

GT39

GlyCosmos Glycogenes

POMT2

OMIM

607439

Disease name

GDGDB

Human Protein Atlas

ENSG00000009830

Open ALL Close ALL

Orthologous Gene

Mus musculus

mRNA	NM_153415
Protein	NP_700464
MGI	85381

Rattus norvegicus

mRNA	XM_345709
Protein	XP_345709

Caenorhabditis elegans

mRNA	NM_058919
Protein	NP_491320

Drosophila melanogaster

mRNA	NM_130502
Protein	NP_569858

Acceptor Substrates (Reference)

Glycobiology 2002-11-01 ;12(11):771-83.

Characterization of POMT2, a novel member of the PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids.

Willer T. et al. PMID:12460945

Proc. Natl. Acad. Sci. U.S.A. 2004-01-01 ;101(2):500-5.

Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity.

Manya H. et al. PMID:14699049

DONOR : Dol-P-Man

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

		Dol-P-Man

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Glycobiology 2002-11-01 ;12(11):771-83.

Characterization of POMT2, a novel member of the PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids.

Willer T. et al. PMID:12460945

braineyeheartkidneyliverlungovarypancreasprostateskeletal musclesmooth musclespleentestisthymusthyroid glanduterus

Gene Ontology

Provided by GOA

Function
dolichyl-phosphate-mannose-protein mannosyltransferase activity
metal ion binding

Process
cell wall mannoprotein biosynthetic process
chain elongation of O-linked mannose residue
multicellular organism development
protein O-linked glycosylation
protein O-linked mannosylation
regulation of endoplasmic reticulum unfolded protein response

Component
dolichyl-phosphate-mannose-protein mannosyltransferase complex
endoplasmic reticulum membrane
integral component of membrane

This page does not indicate all of the enzymatic reaction, and expression of "POMT2".