GGDB:

ALG2は小胞体での脂質結合型糖鎖の合成に関わるアルファマンノース転移酵素をコードする。GDPマンノースが供与体基質として用いられる。ALG2は、アルファ1,3およびアルファ1,6結合マンノース両方の転移に関連しているとみられる。ALG2は酵母のalg2欠損変異を相補する。ALG2の変異は先天性グリコシル化異常症１I型に関連する。

Keyword: 先天性グリコシル化異常症 , 脂質結合型糖鎖


JCGG-STR024580 GlyTouCan: G65996GC GlyCosmos Glycans: G65996GC		JCGG-STR026178 GlyTouCan: G53394BX GlyCosmos Glycans: G53394BX


JCGG-STR026178 GlyTouCan: G53394BX GlyCosmos Glycans: G53394BX		JCGG-STR026209 GlyTouCan: G43547MI GlyCosmos Glycans: G43547MI

Mannosyltransferases

GGDB Symbol

ALG2 Alias

Designation

GDP-Mannose:ManGlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase, GDP-Mannose:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

Organism

Homo sapiens

GeneID

85365

HGNC

ALG2 (23159)

mRNA

NM_033087

map

9q22-31

Protein

NP_149078

EC#

2.4.1.132

CAZy

GT4

GlyCosmos Glycogenes

ALG2

OMIM

607905

Disease name

先天性糖鎖異常症Ii型

GDGDB

CON00351

Human Protein Atlas

ENSG00000119523

Mus musculus

mRNA	NM_019998
Protein	NP_064382

Rattus norvegicus

mRNA	XM_232987
Protein	XP_232987

Caenorhabditis elegans

mRNA	NM_062609
Protein	NP_495010

Drosophila melanogaster

mRNA	NM_139515
Protein	NP_647772

Saccharomyces cerevisiae

mRNA	Z72587
Protein	CAA96768

Arabidopsis thaliana

mRNA	NM_106527
Protein	NP_178001

J. Biol. Chem. 2003-06-01 ;278(25):22498-505.

A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis.

Thiel C. et al. PMID:12684507

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Provided by GOA

Function
GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
alpha-1,3-mannosyltransferase activity
calcium-dependent protein binding
protein N-terminus binding
protein binding
protein heterodimerization activity

Process
dolichol-linked oligosaccharide biosynthetic process
mannosylation
protein glycosylation in endoplasmic reticulum
response to calcium ion

Component
cytoplasm
endoplasmic reticulum membrane
integral component of membrane
membrane
nucleus
perinuclear region of cytoplasm

ALG2

Mannosyltransferases

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Saccharomyces cerevisiae

Arabidopsis thaliana

Acceptor Substrates (Reference)

A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Gene Ontology