ALG3 encodes alpha-1,3-mannosyltransferase that is involved in the synthesis of lipid-linked oligosaccharides in the endoplasmic reticulum. Dolichol-phosphate-mannose is used for the donor substrate. ALG3 complements the defect of the yeast alg3 mutant. Mutation of ALG3 is associated with congenital disorder of glycosylation type 1D.
Keyword:
congenital disorders of glycosylation
, lipid-linked oligosaccharide
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JCGG-STR028026
GlyTouCan:
G59406KS
GlyCosmos Glycans:
G59406KS
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JCGG-STR000132
GlyTouCan:
G44865OQ
GlyCosmos Glycans:
G44865OQ
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Mannosyltransferases
| ALG3 Alias | |
| Designation | Dol-P-Mannose:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase |
| Organism | Homo sapiens |
| GeneID | 10195 |
| HGNC | ALG3 (23056) |
| mRNA | NM_005787 |
| map | 3q27.1 |
| Protein | NP_005778 |
| EC# | 2.4.1.130 |
| CAZy | GT58 |
| GlyCosmos Glycogenes | ALG3 |
| OMIM | 608750 |
| CDG Id , Congenital Disorder of Glycosylation type Id | |
| GDGDB | CON00346 |
| Human Protein Atlas | ENSG00000214160 |
Mus musculus
Rattus norvegicus
Caenorhabditis elegans
Drosophila melanogaster
Saccharomyces cerevisiae
Arabidopsis thaliana