ALG5 encodes dolichol-phosphate glucosyltransferase that is involved in the synthesis of lipid-linked oligosaccharides in the endoplasmic reticulum. UDP-glucose and dolichol-phosphate are used as donor and acceptor substrates, respectively.
Keyword:
dolichol-phosphate-glucose
dolichol-phosphate
|
UDP-Glc
|
dolichol-phosphate-glucose
|
|
|
|
Glucosyltransferase
GGDB Symbol |
ALG5
Alias
HGNC Symbol
|
: |
ALG5
|
clone name
|
: |
RP11-421P11.2
|
unknown
|
: |
bA421P11.2
|
|
|
|
Designation | asparagine-linked glycosylation 5, dolichol-phosphate beta-glucosyltransferase homolog (S. cerevisiae) |
Organism | Homo sapiens |
GeneID |
29880
|
HGNC |
ALG5
(20266)
|
mRNA |
NM_013338
|
map | 13q13.3 |
Protein |
NP_037470
|
EC# |
2.4.1.117
|
CAZy |
GT2
|
GlyCosmos Glycogenes |
ALG5
|
OMIM |
604565
|
Disease name |
|
GDGDB |
|
Human Protein Atlas |
ENSG00000120697
|
Proc. Natl. Acad. Sci. U.S.A. 1999-06-01 ;96(12):6982-7.
A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic.
Imbach T. et al.
PMID:10359825
brainheartkidneyliverpancreasplacentaskeletal muscle
This page does not indicate all of the enzymatic reaction, and expression of "ALG5".