ALG6 encodes alpha-1,3-glucosyltransferase that is involved in the synthesis of lipid-linked oligosaccharides in the endoplasmic reticulum. Dolichol-phosphate-glucose is used for the donor substrate. ALG6 complements the defect of the yeast alg6 mutant. Mutation of ALG6 is associated with congenital disorder of glycosylation type 1C.
Keyword:
congenital disorders of glycosylation
, lipid-linked oligosaccharide
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JCGG-STR028843
GlyTouCan:
G39578OU
GlyCosmos Glycans:
G39578OU
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JCGG-STR000072
GlyTouCan:
G24620AI
GlyCosmos Glycans:
G24620AI
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Glucosyltransferase
| ALG6 Alias | |
| Designation | Dol-P-Glucose:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase |
| Organism | Homo sapiens |
| GeneID | 29929 |
| HGNC | ALG6 (23157) |
| mRNA | NM_013339 |
| map | 1p31.3 |
| Protein | NP_037471 |
| EC# | |
| CAZy | GT57 |
| GlyCosmos Glycogenes | ALG6 |
| OMIM | 604566 |
| CDG Ic , Congenital Disorder of Glycosylation type Ic | |
| GDGDB | CON00345 |
| Human Protein Atlas | ENSG00000088035 |
Mus musculus
Rattus norvegicus
Caenorhabditis elegans
Drosophila melanogaster
Saccharomyces cerevisiae
Arabidopsis thaliana