ALG8 encodes alpha-1,3-glucosyltransferase that is involved in the synthesis of lipid-linked oligosaccharides in the endoplasmic reticulum. Dolichol-phosphate-glucose is used for the donor substrate. Mutation of ALG8 is associated with congenital disorder of glycosylation type 1H.
Keyword:
congenital disorders of glycosylation
, lipid-linked oligosaccharide
|
|
|
|
JCGG-STR000072
GlyTouCan:
G24620AI
GlyCosmos Glycans:
G24620AI
|
JCGG-STR024581
GlyTouCan:
G98256YA
GlyCosmos Glycans:
G98256YA
|
Glucosyltransferase
| ALG8 Alias | |
| Designation | Dol-P-Glucose:GlcMan9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase |
| Organism | Homo sapiens |
| GeneID | 79053 |
| HGNC | ALG8 (23161) |
| mRNA | NM_024079 |
| map | 11q14.1 |
| Protein | NP_076984 |
| EC# | |
| CAZy | GT57 |
| GlyCosmos Glycogenes | ALG8 |
| OMIM | 608103 |
| CDG Ih , Congenital Disorder of Glycosylation type Ih | |
| GDGDB | CON00350 |
| Human Protein Atlas | ENSG00000159063 |
Mus musculus
Rattus norvegicus
Caenorhabditis elegans
Drosophila melanogaster
Saccharomyces cerevisiae
Arabidopsis thaliana