GGDB:

ALG10 encodes alpha-1,2-glucosyltransferase that is involved in the synthesis of lipid-linked oligosaccharides in the endoplasmic reticulum. Dolichol-phosphate-glucose is used for the donor substrate.

Keyword: lipid-linked oligosaccharide


JCGG-STR024581 GlyTouCan: G98256YA GlyCosmos Glycans: G98256YA		JCGG-STR028873 GlyTouCan: G72079JG GlyCosmos Glycans: G72079JG

Glucosyltransferase

GGDB Symbol

ALG10 Alias

Designation

Dol-P-Glucose:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase

Organism

Homo sapiens

GeneID

84920

HGNC

ALG10 (23162)

mRNA

NM_032834

map

12p11.1

Protein

NP_116223

EC#

CAZy

GT59

GlyCosmos Glycogenes

ALG10

OMIM

603313

Disease name

GDGDB

Human Protein Atlas

ENSG00000139133

Mus musculus

mRNA	XM_354869
Protein	XP_354869

Rattus norvegicus

mRNA	NM_139101
Protein	NP_620801

Caenorhabditis elegans

mRNA	NM_060233
Protein	NP_492634

Drosophila melanogaster

mRNA	NM_168449
Protein	NP_729680

Saccharomyces cerevisiae

mRNA	Z73012
Protein	CAA97255

Glycobiology 1998-05-01 ;8(5):455-62.

The ALG10 locus of Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of the lipid-linked oligosaccharide is required for efficient N-linked glycosylation.

Burda P. et al. PMID:9597543

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Provided by GOA

Function
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity

Process
dolichol-linked oligosaccharide biosynthetic process
protein glycosylation

Component
endoplasmic reticulum membrane
integral component of membrane

ALG10

Glucosyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Saccharomyces cerevisiae

Acceptor Substrates (Reference)

The ALG10 locus of Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of the lipid-linked oligosaccharide is required for efficient N-linked glycosylation.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Gene Ontology