GGDB:

UGGT1あるいはUDP-グルコース糖タンパク質グルコシルトランスフェラーゼ1は変性糖タンパク質の高マンノース型N-グリカンをグルコシル化する。UGGT1はUGTあるいはUDP-グルコースセラミドグルコシルトランスフェラーゼ様分子1(UGCGL1)とも知られる。UGGT1は可溶性酵素として小胞体に局在しており、小胞体からゴルジへのタンパク質輸送における品質管理に関わっている。

Keyword:

	UDP-Glc
JCGG-STR015500 GlyTouCan: G60230HH GlyCosmos Glycans: G60230HH		JCGG-STR029785 GlyTouCan: G19958IL GlyCosmos Glycans: G19958IL

	UDP-Glc
JCGG-STR026135 GlyTouCan: G91704UR GlyCosmos Glycans: G91704UR		JCGG-STR003811 GlyTouCan: G39687WG GlyCosmos Glycans: G39687WG

	UDP-Glc
JCGG-STR015286 GlyTouCan: G40702WU GlyCosmos Glycans: G40702WU		JCGG-STR003629 GlyTouCan: G81356NS GlyCosmos Glycans: G81356NS

	UDP-Glc
JCGG-STR015069 GlyTouCan: G68668TB GlyCosmos Glycans: G68668TB		JCGG-STR003809 GlyTouCan: G32149KV GlyCosmos Glycans: G32149KV

Glucosyltransferase

GGDB Symbol

UGGT1 (UGCGL1) Alias

Designation

UDP-glucose:glycoprotein glucosyltransferase 1

Organism

Homo sapiens

GeneID

56886

HGNC

UGGT1 (15663)

mRNA

NM_020120

map

2p14.3

Protein

NP_064505

EC#

CAZy

GT24

GlyCosmos Glycogenes

UGGT1 (UGCGL1)

OMIM

605897

Disease name

GDGDB

Human Protein Atlas

ENSG00000136731

Mus musculus

mRNA	NM_198899
Protein	NP_942602
MGI	84314

Rattus norvegicus

mRNA	NM_133596
Protein	NP_598280

Caenorhabditis elegans

mRNA	NM_076867
Protein	NP_509268

Drosophila melanogaster

mRNA	NM_079427
Protein	NP_524151

Saccharomyces cerevisiae

mRNA	Z75244
Protein	CAA99659

Arabidopsis thaliana

mRNA	NM_105791
Protein	NP_177278

EMBO J. 2000-03-01 ;39(9):2149-63.

Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.

Arnold SM. et al. PMID:10694380

Biochemistry 2000-04-01 ;10(4):403-12.

Cloning and characterization of mammalian UDP-glucose glycoprotein: glucosyltransferase and the development of a specific substrate for this enzyme.

Tessier DC. et al. PMID:10764828

EMBO J. 1995-09-01 ;14(17):4196-203.

The molecular basis for the recognition of misfolded glycoproteins by the UDP-Glc:glycoprotein glucosyltransferase.

Sousa M. et al. PMID:7556060

DONOR : UDP-Glc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR015500 GlyTouCan: G60230HH GlyCosmos Glycans: G60230HH	UDP-Glc	JCGG-STR029785 GlyTouCan: G19958IL GlyCosmos Glycans: G19958IL

	JCGG-STR026135 GlyTouCan: G91704UR GlyCosmos Glycans: G91704UR	UDP-Glc	JCGG-STR003811 GlyTouCan: G39687WG GlyCosmos Glycans: G39687WG

	JCGG-STR015286 GlyTouCan: G40702WU GlyCosmos Glycans: G40702WU	UDP-Glc	JCGG-STR003629 GlyTouCan: G81356NS GlyCosmos Glycans: G81356NS

	JCGG-STR015069 GlyTouCan: G68668TB GlyCosmos Glycans: G68668TB	UDP-Glc	JCGG-STR003809 GlyTouCan: G32149KV GlyCosmos Glycans: G32149KV

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

EMBO J. 2000-03-01 ;39(9):2149-63.

Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.

Arnold SM. et al. PMID:10694380

brainheartkidneyliverlungpancreasplacentaskeletal muscle

Provided by GOA

Function
UDP-glucose:glycoprotein glucosyltransferase activity
protein binding
unfolded protein binding

Process
'de novo' posttranslational protein folding
ER-associated misfolded protein catabolic process
UDP-glucosylation
endoplasmic reticulum mannose trimming
endoplasmic reticulum unfolded protein response
protein N-linked glycosylation via asparagine

Component
endoplasmic reticulum
endoplasmic reticulum-Golgi intermediate compartment
endoplasmic reticulum lumen
endoplasmic reticulum quality control compartment
extracellular exosome

UGGT1 (UGCGL1)

Glucosyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Saccharomyces cerevisiae

Arabidopsis thaliana

Acceptor Substrates (Reference)

Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.

Cloning and characterization of mammalian UDP-glucose glycoprotein: glucosyltransferase and the development of a specific substrate for this enzyme.

The molecular basis for the recognition of misfolded glycoproteins by the UDP-Glc:glycoprotein glucosyltransferase.

DONOR : UDP-Glc

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.

Gene Ontology