UGCG

Last Update:2016-01-29

UGCG is a UDP-glucose ceramide glucosyltransferase,which transfers glucose to a ceramide, synthesizing a glucosylceramide (GlcCer). UGCG is also knoan as b-glucosyltransferase (GlcT-I) or glucosylceramide synthase (GCS). GlcCer is a key precursor lipid for the synthesis of glycosphingolipids. Lack of UGCG resulted in embryonic lethality,indicating a vital role of glycosphingolipids during development and differentiation.

Keyword:
Cer
UDP-Glc 		Glc-Cer

Glucosyltransferase


GGDB Symbol UGCG    Alias
DesignationUDP-glucose ceramide glucosyltransferase
OrganismHomo sapiens
GeneID 7357
HGNC UGCG (12524)
mRNA NM_003358
map9q31
Protein NP_003349
EC# 2.4.1.80   
CAZy GT21   
GlyCosmos Glycogenes UGCG
OMIM 602874
Disease name
GDGDB
Human Protein Atlas ENSG00000148154
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "UGCG".