GGDB:

This enzyme is one from the group of enzymes involved in the synthesis of the HNK-1 carbohydrate antigen (HSO3-GlcAb1-3Galb1-4GlcNAc-R), and its enzymatic activity includes an activity that transfers a glucuronic acid (GlcA) from the donor UDP-GlcA to a galactose residue of the non-reducing terminal of the acceptor (Galb1-4GlcNAc-R) by the a1-3 bond. It is also known as Glucuronyltransferase S (GlcAT-S) as an alias.

Keyword: GlcAT-S , HNK-1(Human Natural Killer-1) , UDP-GlcA , glucuronyltransferase

	UDP-GlcA
JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO		JCGG-STR007574 GlyTouCan: G10271ZL GlyCosmos Glycans: G10271ZL

Glucuronyltransferase

GGDB Symbol

B3GAT2 Alias

Designation

beta-1,3-glucuronyltransferase 2

Organism

Homo sapiens

GeneID

135152

HGNC

B3GAT2 (922)

mRNA

NM_080742

map

6q13

Protein

NP_542780

EC#

2.4.1.135

CAZy

GT43

GlyCosmos Glycogenes

B3GAT2

OMIM

607497

Disease name

GDGDB

Human Protein Atlas

ENSG00000112309

Mus musculus

mRNA	NM_172124
Protein	NP_742122
KO_mice_database	7
MGI	82325

Rattus norvegicus

mRNA	NM_022609
Protein	NP_072131

J. Hum. Genet. 1999-02-01 ;255(1):182-7.

Molecular cloning and expression of a second glucuronyltransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope.

Seiki T. et al. PMID:10082676

J. Hum. Genet. 2002-01-01 ;47(12):677-80.

Cloning, characterization, and chromosome mapping of the human GlcAT-S gene.

Marcos I. et al. PMID:12522689

J. Hum. Genet. 2005-02-01 ;15(2):203-10.

Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate.

Kakuda S. et al. PMID:15470230 Refer to: Table1,3

DONOR : UDP-GlcA

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	UDP-GlcA	JCGG-STR007574 GlyTouCan: G10271ZL GlyCosmos Glycans: G10271ZL

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Hum. Genet. 2002-01-01 ;47(12):677-80.

Cloning, characterization, and chromosome mapping of the human GlcAT-S gene.

Marcos I. et al. PMID:12522689

adrenal glandsbraintrachea

Provided by GOA

Function
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
metal ion binding

Process
carbohydrate metabolic process
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan biosynthetic process
glycosaminoglycan metabolic process
protein glycosylation

Component
Golgi membrane
integral component of membrane

B3GAT2

Glucuronyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning and expression of a second glucuronyltransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope.

Cloning, characterization, and chromosome mapping of the human GlcAT-S gene.

Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate.

DONOR : UDP-GlcA

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Cloning, characterization, and chromosome mapping of the human GlcAT-S gene.

Gene Ontology