GGDB:

本酵素はHNK-1糖鎖抗原(HSO3-GlcAb1-3Galb1-4GlcNAc-R)の合成に関与する酵素群の一つであり、その酵素活性としては、供与体基質であるUDP-GlcAからグルクロン酸(GlcA)を、受容体基質（Galb1-4GlcNAc-R）の非還元末端に存在するガラクトース残基へとb1-3結合で転移するものである。別名として、Glucuronyltransferase P (GlcAT-P)としても知られている。

Keyword: GlcAT-P , HNK-1(Human Natural Killer-1) , UDP-GlcA , グルクロン酸転移酵素

	UDP-GlcA
JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO		JCGG-STR007574 GlyTouCan: G10271ZL GlyCosmos Glycans: G10271ZL

Glucuronyltransferase

GGDB Symbol

B3GAT1 Alias

Designation

beta-1,3-glucuronyltransferase 1

Organism

Homo sapiens

GeneID

27087

HGNC

B3GAT1 (921)

mRNA

NM_054025

map

11q25

Protein

NP_473361

EC#

2.4.1.135

CAZy

GT43

GlyCosmos Glycogenes

B3GAT1

OMIM

151290

Disease name

GDGDB

Human Protein Atlas

ENSG00000109956

Mus musculus

mRNA	NM_029792
Protein	NP_084068
KO_mice_database	6
MGI	60878

Rattus norvegicus

mRNA	NM_054003
Protein	NP_446455

Caenorhabditis elegans

mRNA	NM_060759
Protein	NP_493160

Drosophila melanogaster

mRNA	NM_167003
Protein	NP_726910

J. Biol. Chem. 2000-04-01 ;65(2):166-73.

Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope.

Mitsumoto Y. et al. PMID:10783264

Genomics 2005-02-01 ;15(2):203-10.

Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate.

Kakuda S. et al. PMID:15470230 Refer to: Table1,3

DONOR : UDP-GlcA

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	UDP-GlcA	JCGG-STR007574 GlyTouCan: G10271ZL GlyCosmos Glycans: G10271ZL

Glycobiology 1998-11-01 ;273(46):30295-300.

Purification and characterization of a glucuronyltransferase involved in the biosynthesis of the HNK-1 epitope on glycoproteins from rat brain.

Terayama K. et al. PMID:9804790

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2000-04-01 ;65(2):166-73.

Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope.

Mitsumoto Y. et al. PMID:10783264

brainliver

Provided by GOA

Function
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
metal ion binding

Process
carbohydrate metabolic process
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan biosynthetic process
glycosaminoglycan metabolic process
protein glycosylation

Component
Golgi membrane
integral component of membrane

B3GAT1

Glucuronyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope.

Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate.

DONOR : UDP-GlcA

Substrate Transferred

Purification and characterization of a glucuronyltransferase involved in the biosynthesis of the HNK-1 epitope on glycoproteins from rat brain.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope.

Gene Ontology