Last Update:2021-12-17

EXTL1 encodes exostosin-like glycosyltransferase 1. This gene belongs to the multiple exostoses (EXT) family and is involved in heparan sulfate and heparin biosynthesis. The major structure of heparan sulfate is a disaccharide repeating structure consisting of (GlcNAcα1,4GlcAβ1,4). EXTL1 transfers GlcNAc to GlcA at the non-reducing end via α1,4 linkage mainly during chain lengthening.

Keyword: heparan sulfate ,  heparin ,  proteoglycan


GGDB Symbol EXTL1    Alias
Designationheparan sulfate GlcA/GlcNAc transferase like 1
OrganismHomo sapiens
GeneID 2134
HGNC EXTL1 (3515)
mRNA NM_004455
Protein NP_004446
CAZy GT47   
GlyCosmos Glycogenes EXTL1
OMIM 601738
Disease name
Human Protein Atlas ENSG00000158008
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)


RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "EXTL1".