CHSY1 |
Last Update:2021-12-17 |
CHSY1 encodes chondroitin sulfate synthase 1, which is involved in the biosynthesis of chondroitin sulfate. CHSY1 has two glycosyltransferase domains, β1,3GT domain and β1,4GT domain, and forms a complex with CHSY3, CHPF, and CHPF2 to exert GalNAc-transferase and GlcA-transferase activities, which are thought to be responsible for the elongation of chondroitin chains. Various combinations of CHSY, CHSY3, CHPF, and CHPF2 have been reported to produce different lengths of chondroitin chains. CHSY1 is the causative gene of temtamy preaxial brachydactyly syndrome.
CHSY1 Alias | |
Designation | chondroitin sulfate synthase 1, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1 |
Organism | Homo sapiens |
GeneID | 22856 |
HGNC | CHSY1 (17198) |
mRNA | NM_014918 |
map | 15q26.3 |
Protein | NP_055733 |
EC# | |
CAZy | GT31 |
GlyCosmos Glycogenes | CHSY1 |
OMIM | 608183 |
GDGDB | |
Human Protein Atlas | ENSG00000131873 |
mRNA | XM_194358 |
---|---|
Protein | XP_194358 |
MGI | 93929 |
mRNA | XM_218759 |
---|---|
Protein | XP_218759 |
mRNA | AB088397 |
---|---|
Protein | BAC76780 |
mRNA | NM_206717 |
---|---|
Protein | NP_996440 |
Glc |
Man |
Gal |
GlcNAc |
GalNAc |
Fuc |
Xyl |
Neu5Ac |
Neu5Gc |
GlcA |
IdoA |
GlcN |
---|
Glycoprotein | Enzyme activity |
---|---|
Asialo-ovine submaxillary mucin | 0 |
[alpha]-thrombomodulin | 0 |
a-Thrombomodulin | 0 |
Glc |
Man |
Gal |
GlcNAc |
GalNAc |
Fuc |
Xyl |
Neu5Ac |
Neu5Gc |
GlcA |
IdoA |
GlcN |
---|
GlyTouCan:
G76533UX
GlyCosmos Glycans:
G76533UX
|
|
GlyTouCan:
G70907ST
GlyCosmos Glycans:
G70907ST
|
|
GlyTouCan:
G70907ST
GlyCosmos Glycans:
G70907ST
|
|
GlyTouCan:
G33235EO
GlyCosmos Glycans:
G33235EO
|
|
GlyTouCan:
G34103VG
GlyCosmos Glycans:
G34103VG
|
|
GlyTouCan:
G34103VG
GlyCosmos Glycans:
G34103VG
|
|
data available from v22.proteinatlas.org
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Golgi cisterna membrane |
Golgi membrane |
extracellular region |
integral component of membrane |
membrane |