CSS3 (CHSY3) encodes chondroitin sulfate synthase 3, which is involved in the biosynthesis of chondroitin sulfate. CSS3 (CHSY3) has two glycosyltransferase domains, β1,3GT and β1,4GT, and forms a complex with CHSY1, CHPF, and CHPF2 to exert GalNAc-transferase and GlcA-transferase activities and is responsible for the elongation of chondroitin chains. The expression level of CSS3 (CHSY3) is lower than that of CHSY1, and its enzymatic activity is weaker.
Keyword:
chondroitin
, chondroitin sulfate
, proteoglycan
N-Acetylgalactosaminyltransferase Glucuronyltransferase
| CSS3 Alias | |
| Designation | chondroitin sulfate synthase 3, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3 |
| Organism | Homo sapiens |
| GeneID | 337876 |
| HGNC | CHSY3 (24293) |
| mRNA | AB086062 |
| map | 5q23.3 |
| Protein | BAC98832 |
| EC# | |
| CAZy | GT31 |
| GlyCosmos Glycogenes | CSS3 |
| OMIM | 609963 |
| GDGDB | |
| Human Protein Atlas | ENSG00000198108 |
Mus musculus
Rattus norvegicus
