SLC35A2 encodes a UDP-galactose transporter that is localized in the Golgi membrane. It is also known as UGT1. The encoded protein has multiple membrane-spanning regions. UDP-galactose is transported into the Golgi lumen and used as a glycosyl donor for glycan synthesis. It also transports UDP-N-acetylgalactosamine in addition to UDP-galactose. Mutation of SLC35A2 is associated with congenital disorder of glycosylation type 2M.
Keyword:
UDP-N-acetylgalactosamine
, UDP-galactose
, UGT
, congenital disorder of glycosylation
, nucleotide sugar transporter
Nucleotide Sugar Transporter
| SLC35A2 Alias | |
| Designation | UDP-galactose transporter |
| Organism | Homo sapiens |
| GeneID | 7355 |
| HGNC | SLC35A2 (11022) |
| mRNA | NM_005660 |
| map | Xp11.23-p11.22 |
| Protein | NP_005651 |
| EC# | |
| CAZy | |
| GlyCosmos Glycogenes | SLC35A2 |
| OMIM | 314375 |
| GDGDB | |
| Human Protein Atlas | ENSG00000102100 |
Mus musculus
Drosophila melanogaster