GGDB:

SLC35D1はUGTREL7とも知られ、ゴルジ膜に局在する二重基質特異性を持つUDP-グルクロン酸（UDP-GlcA）／UDP-N-アセチルガラクトサミン（UDP-GalNAc）輸送体をエンコードする。エンコードされたタンパク質は、複数の膜貫通領域を持つ。UDP-GlcAおよびUDP-GalNAcはゴルジ内腔に運ばれ糖鎖合成において糖供与体として利用される。

Keyword: UDP-N-アセチルガラクトサミン , UDP-グルクロン酸 , UGT , 糖ヌクレオチド輸送体

Nucleotide Sugar Transporter

GGDB Symbol

SLC35D1 Alias

Designation

UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter

Organism

Homo sapiens

GeneID

23169

HGNC

SLC35D1 (20800)

mRNA

NM_015139

map

1p32-p31

Protein

NP_055954

EC#

CAZy

GlyCosmos Glycogenes

SLC35D1

OMIM

610804

Disease name

GDGDB

Human Protein Atlas

ENSG00000116704

Mus musculus

mRNA	NM_177732
Protein	NP_808400

Rattus norvegicus

mRNA	XM_216462
Protein	XP_216462

Caenorhabditis elegans

mRNA	NM_063035
Protein	NP_495436

Drosophila melanogaster

mRNA	NM_079402
Protein	NP_524126

J. Biol. Chem. 2001-04-01 ;495(1-2):87-93.

Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity.

Muraoka M. et al. PMID:11322953

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2004-06-01 ;279(25):26469-74.

Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.

Suda T. et al. PMID:15082721

adrenal glandscolonfetal liverkidneyliverlungmammary glandpancreasperipheral blood leukocyteplacentasalivary glandskeletal musclesmall intestinespinal cordtestisthyroid glandtracheauterus

Provided by GOA

Function
UDP-glucuronic acid transmembrane transporter activity
pyrimidine nucleotide-sugar transmembrane transporter activity

Process
UDP-glucuronate biosynthetic process
UDP-glucuronic acid transport
carbohydrate transport
chondroitin sulfate biosynthetic process
embryonic skeletal system development
pyrimidine nucleotide-sugar transmembrane transport

Component
endoplasmic reticulum membrane
integral component of membrane

SLC35D1

Nucleotide Sugar Transporter

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.

Gene Ontology