GGDB:

SLC35D2 encodes a nucleotide-sugar transporter that is localized in the Golgi membrane. It has the ability to transport UDP-glucose (UDP-Glc), UDP-N-acetylglucosamine (UDP-GlcNAc) and GDP-Mannose (GDP-Man). SLC35D2 transports UDP-GlcNAc and UDP-Glc in the mammalian cells, but transports GDP-Man alone in the yeast. It is also known as HFRC1 or UGTREL8, and involved in the synthesis of heparan sulfate by regulating the level of UDP-GlcNAc.

Keyword: UDP-N-acetylglucosamine , UGT , nucleotide sugar transporter

Nucleotide Sugar Transporter

GGDB Symbol

SLC35D2 Alias

Designation

UDP-N-acetylglucosamine transporter(fringe connection)

Organism

Homo sapiens

GeneID

11046

HGNC

SLC35D2 (20799)

mRNA

NM_007001

map

9q22.32

Protein

NP_008932

EC#

CAZy

GlyCosmos Glycogenes

SLC35D2

OMIM

609182

Disease name

GDGDB

Human Protein Atlas

ENSG00000130958

Mus musculus

mRNA	NM_001001321
Protein	NP_001001321

Rattus norvegicus

mRNA	XM_214408
Protein	XP_214408

Genomics 2004-06-01 ;279(25):26469-74.

Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.

Suda T. et al. PMID:15082721

J. Biol. Chem. 2005-01-01 ;85(1):106-16.

Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.

Ishida N. et al. PMID:15607426

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Genomics 2004-06-01 ;279(25):26469-74.

Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.

Suda T. et al. PMID:15082721

J. Biol. Chem. 2005-01-01 ;85(1):106-16.

Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.

Ishida N. et al. PMID:15607426

aderenal glandcolonfetal liverheartkidneyliverlungmammary glandpancreasperipheral blood leukocyteplacentasalivary glandskeletal musclesmall intestinespinal cordspleentestisthyroid glandtracheauterus

Provided by GOA

Function
nucleotide-sugar transmembrane transporter activity
pyrimidine nucleotide-sugar transmembrane transporter activity

Process
biological_process
carbohydrate transport
glycosaminoglycan biosynthetic process
keratan sulfate biosynthetic process
keratan sulfate synthesis
pyrimidine nucleotide-sugar transmembrane transport

Component
Golgi membrane
cellular_component
integral component of membrane

SLC35D2

Nucleotide Sugar Transporter

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.

Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.

Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.

Gene Ontology