GGDB:

This enzyme is the enzyme that synthesizes A antigen, which is the blood group carbohydrate antigen, encoded by the ABO gene. Its enzyme activity is a1,3-N-acetylgalactosaminyltransferase activity that transfers GalNAc from the donor UDP-GalNAc to the galactose residue of the non-reducing terminal of the acceptor (H type carbohydrate antigen) by an a1-3 bond.

Keyword: A blood type , Histo-Blood group antigen , a1,3-N-acetylgalactosaminyltransferase

N-Acetylgalactosaminyltransferase

GGDB Symbol

A(ABO) Alias

Designation

alpha 1,3-N-acetylgalactosaminytransferase

Organism

Homo sapiens

GeneID

HGNC

ABO (79)

mRNA

J05175

map

9q34.1-q34.2

Protein

AAA36792

EC#

2.4.1.40

CAZy

GT6

GlyCosmos Glycogenes

A(ABO)

OMIM

110300

Disease name

GDGDB

Human Protein Atlas

ENSG00000175164

Mus musculus

mRNA	NM_030718
Protein	NP_109643

Rattus norvegicus

mRNA	NM_023094
Protein	NP_075582

Semin. Hematol. 1990-01-01 ;265(2):1139-45.

Isolation to homogeneity and partial characterization of a histo-blood group A defined Fuc alpha 1----2Gal alpha 1----3-N-acetylgalactosaminyltransferase from human lung tissue.

Clausen H. et al. PMID:2104827 Refer to: Table 1,2,3

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR021430 GlyTouCan: G00068MO GlyCosmos Glycans: G00068MO	UDP-GalNAc	JCGG-STR022204 GlyTouCan: G00066MO GlyCosmos Glycans: G00066MO

Nature 1990-01-01 ;265(2):1146-51.

Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1----2Gal alpha 1----3GalNAc transferase (histo-blood group A transferase) mRNA.

Yamamoto F. et al. PMID:2104828

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR021430 GlyTouCan: G00068MO GlyCosmos Glycans: G00068MO	UDP-GalNAc	JCGG-STR022204 GlyTouCan: G00066MO GlyCosmos Glycans: G00066MO

Semin. Hematol. 1990-11-01 ;265(31):19257-62.

Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions.

Yamamoto F. et al. PMID:2121736

Semin. Hematol. 1990-05-01 ;345(6272):229-33.

Molecular genetic basis of the histo-blood group ABO system.

Yamamoto F. et al. PMID:2333095

Semin. Hematol. 1986-01-01 ;51(3):161-71.

Genetics of ABO, H, Lewis, X and related antigens.

Oriol R. et al. PMID:2433836

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR033516 GlyTouCan: G17425GC GlyCosmos Glycans: G17425GC	UDP-GalNAc	JCGG-STR033517 GlyTouCan: G77636QU GlyCosmos Glycans: G77636QU

	JCGG-STR033518 GlyTouCan: G78693BX GlyCosmos Glycans: G78693BX	UDP-GalNAc	JCGG-STR033519 GlyTouCan: G68488BQ GlyCosmos Glycans: G68488BQ

	JCGG-STR007028 GlyTouCan: G44060QH GlyCosmos Glycans: G44060QH	UDP-GalNAc	JCGG-STR033520 GlyTouCan: G62735WZ GlyCosmos Glycans: G62735WZ

	JCGG-STR011603 GlyTouCan: G98465JN GlyCosmos Glycans: G98465JN	UDP-GalNAc	JCGG-STR015456 GlyTouCan: G37830TX GlyCosmos Glycans: G37830TX

Semin. Hematol. 1989-01-01 ;56(1):1-20.

ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution.

Clausen H. et al. PMID:2464874

J. Biol. Chem. 1981-01-01 ;18(1):39-62.

Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

Hakomori S. et al. PMID:6782678

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR033516 GlyTouCan: G17425GC GlyCosmos Glycans: G17425GC	UDP-GalNAc	JCGG-STR033517 GlyTouCan: G77636QU GlyCosmos Glycans: G77636QU

	JCGG-STR033518 GlyTouCan: G78693BX GlyCosmos Glycans: G78693BX	UDP-GalNAc	JCGG-STR033519 GlyTouCan: G68488BQ GlyCosmos Glycans: G68488BQ

	JCGG-STR033520 GlyTouCan: G62735WZ GlyCosmos Glycans: G62735WZ	UDP-GalNAc	JCGG-STR007028 GlyTouCan: G44060QH GlyCosmos Glycans: G44060QH

	JCGG-STR011603 GlyTouCan: G98465JN GlyCosmos Glycans: G98465JN	UDP-GalNAc	JCGG-STR015456 GlyTouCan: G37830TX GlyCosmos Glycans: G37830TX

DONOR : UDP-GalNAc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

		UDP-GalNAc
	JCGG-STR031452 GlyTouCan: G14380OJ GlyCosmos Glycans: G14380OJ		JCGG-STR031453 GlyTouCan: G89026DU GlyCosmos Glycans: G89026DU

		UDP-GalNAc
	JCGG-STR004807 GlyTouCan: G38351JR GlyCosmos Glycans: G38351JR		JCGG-STR031456 GlyTouCan: G42233WE GlyCosmos Glycans: G42233WE

		UDP-GalNAc
	JCGG-STR031458 GlyTouCan: G76763LN GlyCosmos Glycans: G76763LN		JCGG-STR031459 GlyTouCan: G66367EU GlyCosmos Glycans: G66367EU

		UDP-GalNAc
	JCGG-STR003781 GlyTouCan: G94514IB GlyCosmos Glycans: G94514IB		JCGG-STR003816 GlyTouCan: G27893KR GlyCosmos Glycans: G27893KR

		UDP-GalNAc
	JCGG-STR031490 GlyTouCan: G53542OI GlyCosmos Glycans: G53542OI		JCGG-STR031491 GlyTouCan: G49277CJ GlyCosmos Glycans: G49277CJ

		UDP-GalNAc
	JCGG-STR031487 GlyTouCan: G45304XA GlyCosmos Glycans: G45304XA		JCGG-STR031488 GlyTouCan: G90451QF GlyCosmos Glycans: G90451QF

		UDP-GalNAc
	JCGG-STR021049 GlyTouCan: G94435QH GlyCosmos Glycans: G94435QH		JCGG-STR021050 GlyTouCan: G99315PE GlyCosmos Glycans: G99315PE

		UDP-GalNAc
	JCGG-STR028041 GlyTouCan: G47180UC GlyCosmos Glycans: G47180UC		JCGG-STR031474 GlyTouCan: G05106AU GlyCosmos Glycans: G05106AU

		UDP-GalNAc
	JCGG-STR031477 GlyTouCan: G64904FE GlyCosmos Glycans: G64904FE		JCGG-STR031479 GlyTouCan: G56734EJ GlyCosmos Glycans: G56734EJ

Substrate Not Transferred


	JCGG-STR004625 GlyTouCan: G11647UD GlyCosmos Glycans: G11647UD


	JCGG-STR004557 GlyTouCan: G19749DC GlyCosmos Glycans: G19749DC


	JCGG-STR027300 GlyTouCan: G32723SL GlyCosmos Glycans: G32723SL

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Semin. Hematol. 1990-01-01 ;265(2):1139-45.

Isolation to homogeneity and partial characterization of a histo-blood group A defined Fuc alpha 1----2Gal alpha 1----3-N-acetylgalactosaminyltransferase from human lung tissue.

Clausen H. et al. PMID:2104827

Semin. Hematol. 1986-01-01 ;51(3):161-71.

Genetics of ABO, H, Lewis, X and related antigens.

Oriol R. et al. PMID:2433836

Semin. Hematol. 1989-01-01 ;56(1):1-20.

ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution.

Clausen H. et al. PMID:2464874

J. Biol. Chem. 1981-01-01 ;18(1):39-62.

Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

Hakomori S. et al. PMID:6782678

kidneylung

A(ABO)

N-Acetylgalactosaminyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Isolation to homogeneity and partial characterization of a histo-blood group A defined Fuc alpha 1----2Gal alpha 1----3-N-acetylgalactosaminyltransferase from human lung tissue.

DONOR : UDP-GalNAc

Substrate Transferred

Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1----2Gal alpha 1----3GalNAc transferase (histo-blood group A transferase) mRNA.

DONOR : UDP-GalNAc

Substrate Transferred

Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions.

Molecular genetic basis of the histo-blood group ABO system.

Genetics of ABO, H, Lewis, X and related antigens.

DONOR : UDP-GalNAc

Substrate Transferred

ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution.

Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

DONOR : UDP-GalNAc

Substrate Transferred

Acceptor Substrates (KEM-C)

DONOR : UDP-GalNAc

Substrate Transferred

Substrate Not Transferred

Expression

Expression (Reference)

Isolation to homogeneity and partial characterization of a histo-blood group A defined Fuc alpha 1----2Gal alpha 1----3-N-acetylgalactosaminyltransferase from human lung tissue.

Genetics of ABO, H, Lewis, X and related antigens.

ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution.

Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

Gene Ontology