DPM2 encodes a regulatory subunit of dolichyl-phosphate mannosyltransferase. Dolichol-phosphate-mannose is required for the synthesis of lipid-linked oligosaccharides and glycosylphosphatidylinositol anchor in the endoplasmic reticulum. Dolichyl-phosphate mannosyltransferase consists of three subunits, DPM1, DPM2 and DPM3. GDP-mannose and dolichol-phosphate are used as donor and acceptor substrates, respectively. Mutation of DPM2 is associated with congenital disorder of glycosylation type 1u.
Keyword:
congenital disorders of glycosylation
, dolichol-phosphate-mannose
| dolichol-phosphate | 
|
dolichol-phosphate-mannose |
Mannosyltransferases
| DPM2 Alias | |
| Designation | dolichol-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
| Organism | Homo sapiens |
| GeneID | 8818 |
| HGNC | DPM2 (3006) |
| mRNA | NM_003863 |
| map | 9q34.13 |
| Protein | NP_003854 |
| EC# | 2.4.1.83 |
| CAZy | GT2 |
| GlyCosmos Glycogenes | DPM2 |
| OMIM | 603564 |
| GDGDB | |
| Human Protein Atlas | ENSG00000136908 |
Mus musculus
Rattus norvegicus