POGLUT1

POGLUT1 encodes protein O-glucosyltransferase 1. POGLUT1 transfer Glc directly toward Ser in epidermal growth factor-like (EGF) repeats domains of Notch receptors. POGLUT1 was first identified as rumi, the gene responsible for the Notch phenotype of drosophila. Like POFUT1/2, POGLUT1 has an ER-retaining sequence at its C-terminus, and this reaction is also occured in the endoplasmic reticulum. In addition to Glc-T activity, POGLUT1 also possesses Xly-T activity using UDP-Xyl as a sugar donor substrate. It is the causative gene of Dowling-Degos disease 4, a human hereditary skin disease.