This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT17 is the 17th member of this enzyme family. This is highly homologous to T10, however, suggested specific functions in spermatocytos during meiosis. This isozyme was published as GALNT20 by Peng et al. in 2010.
Keyword:
GALNTL6
, O-glycan
, Tn-antigen
, mucin
, tumor marker
| HO-Ser/Thr-glycopeptide | 
|
GalNAc(alpha1-O)-Ser/Thr-glycopeptide |
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
| GALNT17 | |
| Designation | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 17 |
| Organism | Homo sapiens |
| GeneID | 442117 |
| HGNC | |
| mRNA | NM_001034845.2 |
| map | 4q34.1 |
| Protein | NP_001030017.2 |
| EC# | 2.4.1.41 |
| CAZy | GT27 |
| GlyCosmos Glycogenes | GALNT17 |
| OMIM | 615138 |
| GDGDB | |
| Human Protein Atlas | ENSG00000174473 |
